Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2776757..2777402 Replicon chromosome
Accession NZ_CP098777
Organism Cronobacter sakazakii strain JXES-28

Toxin (Protein)


Gene name higB Uniprot ID A0A6L3QTA3
Locus tag NES82_RS13630 Protein ID WP_004388208.1
Coordinates 2777040..2777402 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6L3TU83
Locus tag NES82_RS13625 Protein ID WP_004388209.1
Coordinates 2776757..2777053 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NES82_RS13615 (NES82_13620) 2774411..2775259 - 849 WP_105572482.1 DNA-3-methyladenine glycosylase 2 -
NES82_RS13620 (NES82_13625) 2775395..2776747 + 1353 WP_252142304.1 molecular chaperone -
NES82_RS13625 (NES82_13630) 2776757..2777053 - 297 WP_004388209.1 XRE family transcriptional regulator Antitoxin
NES82_RS13630 (NES82_13635) 2777040..2777402 - 363 WP_004388208.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NES82_RS13635 (NES82_13640) 2777633..2778880 + 1248 WP_004388207.1 MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit -
NES82_RS13640 (NES82_13645) 2778880..2782002 + 3123 WP_054624226.1 MdtB/MuxB family multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-86)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14197.07 Da        Isoelectric Point: 8.0154

>T248067 WP_004388208.1 NZ_CP098777:c2777402-2777040 [Cronobacter sakazakii]
MAWTVIFTDRFNDWYQQQPEGLQDRIAALLWNLRYSGPLVGRPLVDTVKGSRYPNLKELRVQYGGEPWRVFFAFDAERQA
VVLCAGNKRSQKHFYDALIRQAEEEFFLHVQAMERRNENS

Download         Length: 363 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10837.75 Da        Isoelectric Point: 5.8787

>AT248067 WP_004388209.1 NZ_CP098777:c2777053-2776757 [Cronobacter sakazakii]
MKTLDDVMAGFSPERQAEILRMADEIALEHGLPRIREARAFSQQQLAEIMGVTQPAIAAIEQRGKEIKLLTLKRYVEALG
GKLSLLIELPEGSKVIPV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L3QTA3

Antitoxin

Source ID Structure
AlphaFold DB A0A6L3TU83

References