Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2049319..2049884 Replicon chromosome
Accession NZ_CP098777
Organism Cronobacter sakazakii strain JXES-28

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NES82_RS09995 Protein ID WP_032989567.1
Coordinates 2049319..2049597 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag NES82_RS10000 Protein ID WP_004388462.1
Coordinates 2049597..2049884 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NES82_RS09980 (NES82_09985) 2044385..2046322 + 1938 WP_161574961.1 methyl-accepting chemotaxis protein -
NES82_RS09985 (NES82_09990) 2046430..2047416 + 987 WP_007888785.1 SDR family oxidoreductase -
NES82_RS09990 (NES82_09995) 2047418..2049022 - 1605 WP_161574962.1 alpha-amylase family protein -
NES82_RS09995 (NES82_10000) 2049319..2049597 + 279 WP_032989567.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NES82_RS10000 (NES82_10005) 2049597..2049884 + 288 WP_004388462.1 HigA family addiction module antitoxin Antitoxin
NES82_RS10005 (NES82_10010) 2049944..2052061 - 2118 WP_161574963.1 TonB-dependent receptor PqqU -
NES82_RS10010 (NES82_10015) 2052339..2053397 + 1059 WP_038880466.1 YncE family protein -
NES82_RS10015 (NES82_10020) 2053428..2054294 - 867 WP_105551838.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10585.11 Da        Isoelectric Point: 10.0888

>T248062 WP_032989567.1 NZ_CP098777:2049319-2049597 [Cronobacter sakazakii]
MIRSFRHKGLQRYFETGSTAGIHALHARKISLRLAVLNQAIRPADVDLPGFFLHPLTGDRKGIWAVTVSGNWRITFEFRD
GDVFIVNYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10428.03 Da        Isoelectric Point: 8.7791

>AT248062 WP_004388462.1 NZ_CP098777:2049597-2049884 [Cronobacter sakazakii]
MATMFNPPHPGRLVQESMEALGLSARALAKALDVAPSTVQRLLVGKSDVSPEMALRLSAVLGSSPHVWLGMQNEYDLFQA
RQSVDFSHLQRLQRA

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References