Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1763925..1764595 Replicon chromosome
Accession NZ_CP098777
Organism Cronobacter sakazakii strain JXES-28

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NES82_RS08740 Protein ID WP_080320917.1
Coordinates 1763925..1764221 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NES82_RS08745 Protein ID WP_032989868.1
Coordinates 1764254..1764595 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NES82_RS08720 (NES82_08725) 1759540..1760367 - 828 WP_105573149.1 ammonia-dependent NAD(+) synthetase -
NES82_RS08725 (NES82_08730) 1760610..1760951 + 342 WP_004387341.1 osmotically-inducible lipoprotein OsmE -
NES82_RS08730 (NES82_08735) 1761064..1763319 - 2256 WP_161574344.1 catalase HPII -
NES82_RS08735 (NES82_08740) 1763531..1763761 + 231 WP_041460525.1 cell division activator CedA -
NES82_RS08740 (NES82_08745) 1763925..1764221 + 297 WP_080320917.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NES82_RS08745 (NES82_08750) 1764254..1764595 + 342 WP_032989868.1 HigA family addiction module antitoxin Antitoxin
NES82_RS08750 (NES82_08755) 1764706..1766097 - 1392 WP_004386567.1 L-cystine transporter -
NES82_RS08755 (NES82_08760) 1766232..1766822 - 591 WP_004386566.1 metal-dependent hydrolase -
NES82_RS08760 (NES82_08765) 1766936..1767691 - 756 WP_007867041.1 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase KduD -
NES82_RS08765 (NES82_08770) 1767879..1768547 - 669 WP_038859934.1 hexitol phosphatase HxpB -
NES82_RS08770 (NES82_08775) 1768706..1769242 + 537 WP_004386563.1 YniB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11429.94 Da        Isoelectric Point: 9.6980

>T248061 WP_080320917.1 NZ_CP098777:1763925-1764221 [Cronobacter sakazakii]
MQKHIGSFRDAWLAAFFVYSTPHRNIPAEIHTTLARKLDIINAATSYRDLRSPPGNRFEALSGKLQGYSSIRVNHHYRLI
FRWVEGKAEDLYLDPHDY

Download         Length: 297 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12795.80 Da        Isoelectric Point: 8.0052

>AT248061 WP_032989868.1 NZ_CP098777:1764254-1764595 [Cronobacter sakazakii]
MKQATRKPTTPGEILVYEYLEPLGLKINEVAEMLCVHRNSVSALVNNNRKLTTDMAFRLAKAFGTSVDFWLNLQAAVDLW
EVENDMRIQEAFSRIVPAAEFIARRDAQKKAVA

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References