Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 741510..742285 Replicon chromosome
Accession NZ_CP098770
Organism Klebsiella pneumoniae strain TH12845

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag NE242_RS03705 Protein ID WP_004150910.1
Coordinates 741800..742285 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag NE242_RS03700 Protein ID WP_004150912.1
Coordinates 741510..741803 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE242_RS03680 (NE242_03680) 736718..737320 - 603 WP_062954968.1 short chain dehydrogenase -
NE242_RS03685 (NE242_03685) 737418..738329 + 912 WP_004188550.1 LysR family transcriptional regulator -
NE242_RS03690 (NE242_03690) 738330..739478 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
NE242_RS03695 (NE242_03695) 739489..740865 - 1377 WP_004217775.1 cystathionine beta-synthase -
NE242_RS03700 (NE242_03700) 741510..741803 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
NE242_RS03705 (NE242_03705) 741800..742285 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
NE242_RS03710 (NE242_03710) 742989..743582 + 594 WP_004188553.1 hypothetical protein -
NE242_RS03715 (NE242_03715) 743679..743895 + 217 Protein_730 transposase -
NE242_RS03720 (NE242_03720) 744501..745373 + 873 WP_004188557.1 ParA family protein -
NE242_RS03725 (NE242_03725) 745373..745756 + 384 WP_004150906.1 hypothetical protein -
NE242_RS03730 (NE242_03730) 745749..747116 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 743679..743831 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T248044 WP_004150910.1 NZ_CP098770:741800-742285 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT248044 WP_004150912.1 NZ_CP098770:741510-741803 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References