Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 741608..742383 Replicon chromosome
Accession NZ_CP098769
Organism Klebsiella pneumoniae strain TH12846

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag NE243_RS03710 Protein ID WP_004150910.1
Coordinates 741898..742383 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag NE243_RS03705 Protein ID WP_004150912.1
Coordinates 741608..741901 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE243_RS03685 (NE243_03685) 736816..737418 - 603 WP_062954968.1 short chain dehydrogenase -
NE243_RS03690 (NE243_03690) 737516..738427 + 912 WP_004188550.1 LysR family transcriptional regulator -
NE243_RS03695 (NE243_03695) 738428..739576 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
NE243_RS03700 (NE243_03700) 739587..740963 - 1377 WP_004217775.1 cystathionine beta-synthase -
NE243_RS03705 (NE243_03705) 741608..741901 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
NE243_RS03710 (NE243_03710) 741898..742383 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
NE243_RS03715 (NE243_03715) 743087..743680 + 594 WP_004188553.1 hypothetical protein -
NE243_RS03720 (NE243_03720) 743777..743993 + 217 Protein_731 transposase -
NE243_RS03725 (NE243_03725) 744599..745471 + 873 WP_004188557.1 ParA family protein -
NE243_RS03730 (NE243_03730) 745471..745854 + 384 WP_004150906.1 hypothetical protein -
NE243_RS03735 (NE243_03735) 745847..747214 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 743777..743929 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T248030 WP_004150910.1 NZ_CP098769:741898-742383 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT248030 WP_004150912.1 NZ_CP098769:741608-741901 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References