Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 2785703..2786397 Replicon chromosome
Accession NZ_CP098757
Organism Klebsiella oxytoca strain AHC-6

Toxin (Protein)


Gene name yafO Uniprot ID -
Locus tag NDX50_RS13140 Protein ID WP_263441988.1
Coordinates 2785703..2786107 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID A0A285AZA0
Locus tag NDX50_RS13145 Protein ID WP_073395581.1
Coordinates 2786104..2786397 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDX50_RS13120 (NDX50_13110) 2782516..2783352 - 837 WP_064398616.1 DUF2971 domain-containing protein -
NDX50_RS13125 (NDX50_13115) 2783659..2783853 + 195 WP_064372954.1 hypothetical protein -
NDX50_RS13130 (NDX50_13120) 2783840..2784271 - 432 WP_064372953.1 hypothetical protein -
NDX50_RS13135 (NDX50_13125) 2784317..2784952 - 636 WP_064398618.1 DUF4145 domain-containing protein -
NDX50_RS13140 (NDX50_13130) 2785703..2786107 - 405 WP_263441988.1 type II toxin-antitoxin system YafO family toxin Toxin
NDX50_RS13145 (NDX50_13135) 2786104..2786397 - 294 WP_073395581.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
NDX50_RS13150 (NDX50_13140) 2786938..2787837 + 900 WP_201505862.1 DUF4365 domain-containing protein -
NDX50_RS13155 (NDX50_13145) 2787921..2788901 + 981 WP_265782353.1 hypothetical protein -
NDX50_RS13160 (NDX50_13150) 2788978..2790231 + 1254 WP_201505864.1 DUF3644 domain-containing protein -
NDX50_RS13165 (NDX50_13155) 2790272..2790481 + 210 WP_133116564.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2779421..2807051 27630


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(29-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15512.89 Da        Isoelectric Point: 7.1284

>T248000 WP_263441988.1 NZ_CP098757:c2786107-2785703 [Klebsiella oxytoca]
MSIRIFKSALIRQQLIQQELDDLAADFLSYKKDGVLPDTFGRDAPYDDDRTYPLVKEEQVAHIHLADADAPFPKFLRQFK
RTSDQAHLVYCQGAMDPDAYLLIIILKPEAHKMARNNNHMHKIGMMAEAFRMKH

Download         Length: 405 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10979.44 Da        Isoelectric Point: 4.9167

>AT248000 WP_073395581.1 NZ_CP098757:c2786397-2786104 [Klebsiella oxytoca]
MERILAEKSINITELRKNPAKYFIDEPVAVLSNNRPAGYMVSAKVFEELIDLLEEKQGRVHTGARFRPTAERLSDIADSG
QKLLQNASDKDLTEFTE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A285AZA0

References