Detailed information of TA system TA247986

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 18884..19220
• Replicon: plasmid pEFM9-3
• Accession: NZ_CP098746
• Organism: Enterococcus faecalis strain M9

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: NDO76_RS14110
• Protein ID: WP_141435800.1
• Coordinates: 18884..19030 (+)
• Length: 49 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	18964..19220 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NDO76_RS13855	14091..15404	-	1314	WP_002383787.1	hypothetical protein	-
NDO76_RS14105	15394..15525	-	132	WP_000159353.1	hypothetical protein	-
NDO76_RS13860	15528..16391	-	864	WP_000865436.1	DNA/RNA non-specific endonuclease	-
NDO76_RS13865	16381..16824	-	444	WP_001209505.1	hypothetical protein	-
NDO76_RS13870	16821..16964	-	144	WP_000066155.1	hypothetical protein	-
NDO76_RS13875	17038..17973	-	936	WP_002383786.1	hypothetical protein	-
NDO76_RS13880	18115..18312	-	198	WP_001031355.1	hypothetical protein	-
NDO76_RS14110	18884..19030	+	147	WP_141435800.1	putative holin-like toxin	Toxin
-	18964..19220	-	257	-	-	Antitoxin
NDO76_RS13890	19249..19725	-	477	WP_000615486.1	single-stranded DNA-binding protein	-
NDO76_RS13895	19865..21199	-	1335	WP_001036756.1	PcfJ domain-containing protein	-
NDO76_RS13900	21196..21972	-	777	WP_000347505.1	Cas9 inhibitor AcrIIA9 family protein	-
NDO76_RS13905	22134..22400	-	267	WP_001245899.1	hypothetical protein	-
NDO76_RS13910	22407..22589	-	183	WP_001808764.1	hypothetical protein	-
NDO76_RS13915	23007..23495	-	489	WP_001252682.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	prgB/asc10	1..49313	49313

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-48)

Sequences

Toxin

Protein

• Length: 49 a.a.
• Molecular weight: 5382.49 Da
• Isoelectric Point: 10.6867

>T247986 WP_141435800.1 NZ_CP098746:18884-19030 [Enterococcus faecalis]
MNVLPKSIERRSLLSVSESLQLMLAFGGFTLTLITTIVAILNYKDKKK

Nucleotide

• Length: 147 bp

Antitoxin

Nucleotide

• Length: 257 bp

>AT247986 NZ_CP098746:c19220-18964 [Enterococcus faecalis]
CACCGCCACCGCCGTTTAGGCGCGCATGAAAAAAGGTAGGCATTCGCCTACCTTTTCGCACAAAATGTGGTATAATAATT
ATGTAAAGAGGACGTACTGGTAATACGCCCTCATTGATAGCACCGCTAAAGACGGTGGCAGAGTTTTTATAAGTTATTTA
GAAATAACCGGTCTCCTGCTAAAGTGACGGTTATTTCTTTTTGTCTTTATAGTTCAGAATGGCAACAATGGTTGTGATTA
GGGTCAATGTAAACCCA

Structures

Antitoxin