Detailed information of TA system TA247978

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2628397..2628728
• Replicon: chromosome
• Accession: NZ_CP098743
• Organism: Enterococcus faecalis strain M9

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: NDO76_RS12650
• Protein ID: WP_002367458.1
• Coordinates: 2628397..2628540 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2628473..2628728 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NDO76_RS12630 (2623676)	2623676..2623891	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
NDO76_RS12635 (2624030)	2624030..2625022	+	993	WP_002398510.1	biotin--[acetyl-CoA-carboxylase] ligase	-
NDO76_RS12640 (2625189)	2625189..2625827	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
NDO76_RS12645 (2626511)	2626511..2628127	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
NDO76_RS12650 (2628397)	2628397..2628540	+	144	WP_002367458.1	type I toxin-antitoxin system toxin PepG1	Toxin
- (2628473)	2628473..2628728	-	256	NuclAT_3	-	Antitoxin
NDO76_RS12655 (2628730)	2628730..2632521	-	3792	WP_251846720.1	WxL domain-containing protein	-
- (2632862)	2632862..2633075	-	214	NuclAT_5	-	-
- (2633027)	2633027..2633076	+	50	NuclAT_12	-	-
- (2632872)	2632872..2633077	-	206	NuclAT_9	-	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5311.50 Da
• Isoelectric Point: 10.8331

>T247978 WP_002367458.1 NZ_CP098743:2628397-2628540 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 256 bp

>AT247978 NZ_CP098743:c2628728-2628473 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTTGAAATAGGAGGCTCAGGCATTTTTTATTGATGGTCTTTTTAGGGTTGTTGTGCTATAATGA
TAAAGAAAAGAGAGATATGCTTCCAACATATCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGTGTTAATTATTTAAA
AATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAAAGCA
ATGGTAAACATACCAA

Structures

Antitoxin