Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-RNAII/-
Location 2554166..2554428 Replicon chromosome
Accession NZ_CP098743
Organism Enterococcus faecalis strain M9

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag NDO76_RS12320 Protein ID WP_002392696.1
Coordinates 2554285..2554428 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name RNAII
Locus tag -
Coordinates 2554166..2554311 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDO76_RS12305 (2549532) 2549532..2550245 - 714 WP_002354877.1 trehalose operon repressor -
NDO76_RS12310 (2550507) 2550507..2553251 + 2745 WP_016616452.1 glycosyl hydrolase family 65 protein -
NDO76_RS12315 (2553266) 2553266..2553916 + 651 WP_016616451.1 beta-phosphoglucomutase -
- (2553985) 2553985..2554119 + 135 NuclAT_11 - -
- (2554166) 2554166..2554311 + 146 NuclAT_10 - Antitoxin
- (2554166) 2554166..2554352 + 187 NuclAT_4 - -
NDO76_RS12320 (2554285) 2554285..2554428 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
NDO76_RS12325 (2554660) 2554660..2555631 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
NDO76_RS12330 (2555806) 2555806..2556243 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
NDO76_RS12335 (2556376) 2556376..2556930 - 555 WP_251846717.1 Maf family protein -
NDO76_RS12340 (2556955) 2556955..2559087 - 2133 WP_002368469.1 DNA mismatch repair endonuclease MutL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T247974 WP_002392696.1 NZ_CP098743:c2554428-2554285 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 146 bp

>AT247974 NZ_CP098743:2554166-2554311 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGAGATGCGTCAACATACCTCTCTGATGTAGAACCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References