247957

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2776777..2777558 Replicon chromosome
Accession NZ_CP098741
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain HJL222

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag NCG87_RS13360 Protein ID WP_000626099.1
Coordinates 2777067..2777558 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NCG87_RS13355 Protein ID WP_001110452.1
Coordinates 2776777..2777070 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCG87_RS13320 (2772389) 2772389..2773294 + 906 WP_001268200.1 YjiK family protein -
NCG87_RS13325 (2773633) 2773633..2774091 + 459 WP_000502119.1 IS200/IS605-like element IS200F family transposase -
NCG87_RS13330 (2774300) 2774300..2774569 - 270 WP_010989096.1 hypothetical protein -
NCG87_RS13335 (2774577) 2774577..2774792 - 216 WP_001595136.1 hypothetical protein -
NCG87_RS13340 (2774815) 2774815..2775102 - 288 WP_001269916.1 transcriptional regulator RtsB -
NCG87_RS13345 (2775099) 2775099..2775974 - 876 WP_000921674.1 AraC family transcriptional regulator -
NCG87_RS13350 (2776239) 2776239..2776460 - 222 WP_001576552.1 hypothetical protein -
NCG87_RS13355 (2776777) 2776777..2777070 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NCG87_RS13360 (2777067) 2777067..2777558 + 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
NCG87_RS13365 (2777806) 2777806..2778558 - 753 WP_000842434.1 non-specific acid phosphatase -
NCG87_RS13370 (2778661) 2778661..2778735 - 75 Protein_2597 porin family protein -
NCG87_RS13375 (2779767) 2779767..2780144 - 378 WP_000916345.1 EthD family reductase -
NCG87_RS13380 (2780216) 2780216..2780548 + 333 WP_001165471.1 MerR family transcriptional regulator -
NCG87_RS13385 (2780639) 2780639..2780716 + 78 Protein_2600 helix-turn-helix domain-containing protein -
NCG87_RS13395 (2780987) 2780987..2781562 - 576 WP_001188509.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2773633..2774091 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T247957 WP_000626099.1 NZ_CP098741:2777067-2777558 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT247957 WP_001110452.1 NZ_CP098741:2776777-2777070 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References