247956

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2455178..2455780 Replicon chromosome
Accession NZ_CP098741
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain HJL222

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag NCG87_RS11925 Protein ID WP_001159630.1
Coordinates 2455178..2455489 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NCG87_RS11930 Protein ID WP_000362050.1
Coordinates 2455490..2455780 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCG87_RS11890 (2450291) 2450291..2450890 + 600 WP_000965695.1 glucose-1-phosphatase -
NCG87_RS11895 (2450884) 2450884..2451756 + 873 WP_000921427.1 virulence factor BrkB family protein -
NCG87_RS11900 (2451753) 2451753..2452190 + 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
NCG87_RS11905 (2452235) 2452235..2453176 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NCG87_RS11910 (2453191) 2453191..2453637 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NCG87_RS11915 (2453634) 2453634..2453945 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NCG87_RS11920 (2454031) 2454031..2454960 - 930 WP_001127703.1 alpha/beta hydrolase -
NCG87_RS11925 (2455178) 2455178..2455489 + 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NCG87_RS11930 (2455490) 2455490..2455780 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NCG87_RS11935 (2455827) 2455827..2456756 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NCG87_RS11940 (2456753) 2456753..2457388 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NCG87_RS11945 (2457385) 2457385..2458287 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T247956 WP_001159630.1 NZ_CP098741:2455178-2455489 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT247956 WP_000362050.1 NZ_CP098741:2455490-2455780 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References