247940

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 982474..983101 Replicon chromosome
Accession NZ_CP098736
Organism Cupriavidus gilardii strain QJ1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag NDR89_RS14195 Protein ID WP_082371643.1
Coordinates 982820..983101 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NDR89_RS14190 Protein ID WP_276534984.1
Coordinates 982474..982827 (-) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDR89_RS14175 (NDR89_14175) 978401..981283 + 2883 WP_252253540.1 formate dehydrogenase subunit alpha -
NDR89_RS14180 (NDR89_14180) 981387..982193 + 807 WP_252253862.1 formate dehydrogenase accessory sulfurtransferase FdhD -
NDR89_RS14185 (NDR89_14185) 982196..982417 + 222 WP_252253541.1 formate dehydrogenase subunit delta -
NDR89_RS14190 (NDR89_14190) 982474..982827 - 354 WP_276534984.1 HigA family addiction module antitoxin Antitoxin
NDR89_RS14195 (NDR89_14195) 982820..983101 - 282 WP_082371643.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NDR89_RS14200 (NDR89_14200) 983245..983712 - 468 WP_053822307.1 MgtC/SapB family protein -
NDR89_RS14205 (NDR89_14205) 983863..984558 - 696 WP_252253542.1 transglycosylase domain-containing protein -
NDR89_RS14210 (NDR89_14210) 984872..986008 - 1137 WP_252253543.1 HPP family protein -
NDR89_RS14215 (NDR89_14215) 986189..987007 + 819 WP_252253544.1 TOBE domain-containing protein -
NDR89_RS14220 (NDR89_14220) 987104..987781 - 678 WP_252253545.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - sodB / htpB 880974..1097582 216608


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(22-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(19-108)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10702.35 Da        Isoelectric Point: 8.7701

>T247940 WP_082371643.1 NZ_CP098736:c983101-982820 [Cupriavidus gilardii]
MIQSFRCMDTRALFEGKRVARFTNIHAVAERKLQMLESATTLASLMAPPGNRLEILSGNRRGQYSIRVNAQWRICFLWTS
EGPQCVEIVDYHD

Download         Length: 282 bp

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 12948.65 Da        Isoelectric Point: 4.6133

>AT247940 WP_276534984.1 NZ_CP098736:c982827-982474 [Cupriavidus gilardii]
MIEFNNNVGEEFAMARFHNGMRPVHPGEILREEYLVPLDLSIAELAKELHVDTAQIDAIVRGDAGVASEIALRLARYFGG
DAETWLNLQQAYDLKTAEQQIGDAIRSEVAPRKAKAA

Download         Length: 354 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References