Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1235354..1235944 Replicon chromosome
Accession NZ_CP098732
Organism Acinetobacter tibetensis strain Y-23

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M5E07_RS06050 Protein ID WP_044738568.1
Coordinates 1235354..1235635 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag M5E07_RS06055 Protein ID WP_201706383.1
Coordinates 1235660..1235944 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5E07_RS06030 (M5E07_06030) 1233936..1234115 + 180 WP_252223006.1 hypothetical protein -
M5E07_RS06035 (M5E07_06035) 1234179..1234439 + 261 WP_252223009.1 holin -
M5E07_RS06040 (M5E07_06040) 1234423..1234929 + 507 WP_252223012.1 lysozyme -
M5E07_RS06045 (M5E07_06045) 1235100..1235300 + 201 WP_252223015.1 hypothetical protein -
M5E07_RS06050 (M5E07_06050) 1235354..1235635 + 282 WP_044738568.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5E07_RS06055 (M5E07_06055) 1235660..1235944 + 285 WP_201706383.1 HigA family addiction module antitoxin Antitoxin
M5E07_RS06060 (M5E07_06060) 1236188..1236904 + 717 WP_252223018.1 hypothetical protein -
M5E07_RS06065 (M5E07_06065) 1237045..1237608 + 564 WP_252223021.1 hypothetical protein -
M5E07_RS06070 (M5E07_06070) 1237611..1238387 + 777 WP_252223024.1 hypothetical protein -
M5E07_RS06075 (M5E07_06075) 1238421..1238813 - 393 WP_252223027.1 hypothetical protein -
M5E07_RS06080 (M5E07_06080) 1238972..1239769 + 798 WP_252223030.1 BRO family protein -
M5E07_RS06085 (M5E07_06085) 1240682..1240921 + 240 WP_116763258.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1199451..1246442 46991


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10568.07 Da        Isoelectric Point: 9.9524

>T247935 WP_044738568.1 NZ_CP098732:1235354-1235635 [Acinetobacter tibetensis]
MIKSFKHKGLQAFFQTGTTAGIQAAHSAKLRLILAALHAASTVNDLRTPPNWRLHKLSGNLQDQWSLTVNGNWRVIFKFE
DGDVYIVDYLDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10632.18 Da        Isoelectric Point: 5.6423

>AT247935 WP_201706383.1 NZ_CP098732:1235660-1235944 [Acinetobacter tibetensis]
MNMMFNAPHPGEMLREYIGETPVTEAAQALGVTRANLSRILNGHTGISADMAIRLSEALETSPEFWLNLQMQYDLWNASQ
RQRPVIKKLVQDFA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References