Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2386667..2387184 Replicon chromosome
Accession NZ_CP098727
Organism Staphylococcus aureus strain SauR3

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag LC189_RS11525 Protein ID WP_000113262.1
Coordinates 2386918..2387184 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag LC189_RS11520 Protein ID WP_000584499.1
Coordinates 2386667..2386918 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LC189_RS11490 (LC189_011490) 2382365..2383084 + 720 WP_000479576.1 amino acid ABC transporter permease -
LC189_RS11495 (LC189_011495) 2383081..2383812 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
LC189_RS11500 (LC189_011500) 2383909..2385159 - 1251 WP_224876122.1 FemA/FemB family glycyltransferase FmhA -
LC189_RS11505 (LC189_011505) 2385414..2385776 + 363 WP_000819843.1 DUF4467 domain-containing protein -
LC189_RS11510 (LC189_011510) 2385795..2386394 + 600 WP_000162799.1 DsbA family protein -
LC189_RS11515 (LC189_011515) 2386401..2386502 + 102 WP_031867537.1 hypothetical protein -
LC189_RS11520 (LC189_011520) 2386667..2386918 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LC189_RS11525 (LC189_011525) 2386918..2387184 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
LC189_RS11530 (LC189_011530) 2387219..2387290 + 72 WP_223200558.1 hypothetical protein -
LC189_RS11535 (LC189_011535) 2387478..2389025 + 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
LC189_RS11540 (LC189_011540) 2389211..2389678 + 468 WP_000153344.1 SRPBCC domain-containing protein -
LC189_RS11545 (LC189_011545) 2389762..2389947 + 186 WP_000230293.1 hypothetical protein -
LC189_RS11550 (LC189_011550) 2390163..2390987 + 825 WP_000594630.1 formate/nitrite transporter family protein -
LC189_RS11555 (LC189_011555) 2391221..2391757 + 537 WP_070002486.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T247928 WP_000113262.1 NZ_CP098727:2386918-2387184 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT247928 WP_000584499.1 NZ_CP098727:2386667-2386918 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References