Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2328819..2329342 Replicon chromosome
Accession NZ_CP098727
Organism Staphylococcus aureus strain SauR3

Toxin (Protein)


Gene name yoeB Uniprot ID T1YCD0
Locus tag LC189_RS11245 Protein ID WP_000074043.1
Coordinates 2329076..2329342 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YBB2
Locus tag LC189_RS11240 Protein ID WP_000587618.1
Coordinates 2328819..2329076 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LC189_RS11225 (LC189_011225) 2325316..2326065 - 750 WP_000072441.1 CPBP family lipoprotein N-acylation protein LnsB -
LC189_RS11230 (LC189_011230) 2326260..2327837 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
LC189_RS11235 (LC189_011235) 2328005..2328460 - 456 WP_000732090.1 YehR family lipoprotein -
LC189_RS11240 (LC189_011240) 2328819..2329076 + 258 WP_000587618.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LC189_RS11245 (LC189_011245) 2329076..2329342 + 267 WP_000074043.1 Txe/YoeB family addiction module toxin Toxin
LC189_RS11250 (LC189_011250) 2329699..2330775 + 1077 WP_224826905.1 M42 family metallopeptidase -
LC189_RS11255 (LC189_011255) 2331023..2331685 + 663 WP_000923524.1 ATP-binding cassette domain-containing protein -
LC189_RS11260 (LC189_011260) 2331678..2332454 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
LC189_RS11265 (LC189_011265) 2332850..2334037 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10657.45 Da        Isoelectric Point: 10.3584

>T247926 WP_000074043.1 NZ_CP098727:2329076-2329342 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9762.78 Da        Isoelectric Point: 4.1958

>AT247926 WP_000587618.1 NZ_CP098727:2328819-2329076 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T1YCD0

Antitoxin

Source ID Structure
AlphaFold DB T1YBB2

References