Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 59535..60200 Replicon plasmid pYR4
Accession NZ_CP098725
Organism Yersinia ruckeri strain NVI-10571

Toxin (Protein)


Gene name higB Uniprot ID A0A380S9H4
Locus tag ND438_RS17370 Protein ID WP_038251855.1
Coordinates 59877..60200 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ND438_RS17365 Protein ID WP_004720859.1
Coordinates 59535..59831 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND438_RS17345 (ND438_17340) 54832..56757 - 1926 WP_004720847.1 relaxase/mobilization nuclease domain-containing protein -
ND438_RS17350 (ND438_17345) 56759..57103 - 345 WP_004720848.1 plasmid mobilization protein MobA -
ND438_RS17355 (ND438_17350) 57372..57695 + 324 WP_004720850.1 hypothetical protein -
ND438_RS17360 (ND438_17355) 58234..59047 - 814 Protein_55 DUF932 domain-containing protein -
ND438_RS17365 (ND438_17360) 59535..59831 - 297 WP_004720859.1 NadS family protein Antitoxin
ND438_RS17370 (ND438_17365) 59877..60200 - 324 WP_038251855.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ND438_RS17375 (ND438_17370) 60352..60585 + 234 WP_038251853.1 hypothetical protein -
ND438_RS17380 (ND438_17375) 60593..61090 - 498 WP_126940174.1 hypothetical protein -
ND438_RS17385 (ND438_17380) 61087..61446 - 360 WP_126940175.1 DUF3085 domain-containing protein -
ND438_RS17390 (ND438_17385) 62205..62915 - 711 WP_126940176.1 N-6 DNA methylase -
ND438_RS17395 (ND438_17390) 63061..63207 - 147 WP_126940177.1 succinate dehydrogenase flavoprotein subunit -
ND438_RS17400 (ND438_17395) 63293..63649 - 357 WP_126940178.1 hypothetical protein -
ND438_RS17405 (ND438_17400) 64403..64603 - 201 WP_126940179.1 hypothetical protein -
ND438_RS17410 (ND438_17405) 64646..65152 - 507 WP_126940180.1 antirestriction protein ArdA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..76483 76483


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(46-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-82)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12416.31 Da        Isoelectric Point: 8.8371

>T247922 WP_038251855.1 NZ_CP098725:c60200-59877 [Yersinia ruckeri]
MEYLEFIETPVFSRRRAELLPDDDFRALQEHLLKNHDLGDTISKTGGCKKIRWSREGMGKRGGVRVIYYVITKSGRLYLL
LVYPKNEKDDLTEAEKAVLKSISQQIE

Download         Length: 324 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11027.77 Da        Isoelectric Point: 6.7264

>AT247922 WP_004720859.1 NZ_CP098725:c59831-59535 [Yersinia ruckeri]
MKTELFNDLVESMQQMVAIEKGTLSVPAENIHRHRLPDVKSMREASGLKQNEFADVVGVSASLLQSWEQHRRIPSGSSLK
LLMMIERDPAVIDALRTL

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380S9H4

Antitoxin

Source ID Structure

References