Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 1531196..1531801 | Replicon | chromosome |
Accession | NC_014221 | ||
Organism | Truepera radiovictrix DSM 17093 |
Toxin (Protein)
Gene name | graT | Uniprot ID | - |
Locus tag | TRAD_RS07090 | Protein ID | WP_041947734.1 |
Coordinates | 1531196..1531477 (+) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | TRAD_RS07095 | Protein ID | WP_013177922.1 |
Coordinates | 1531493..1531801 (+) | Length | 103 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
TRAD_RS16315 | 1526691..1526855 | - | 165 | WP_013177915.1 | hypothetical protein | - |
TRAD_RS07070 | 1526997..1527650 | + | 654 | WP_148221311.1 | TetR/AcrR family transcriptional regulator C-terminal domain-containing protein | - |
TRAD_RS15685 | 1528035..1528448 | - | 414 | WP_083770752.1 | phage integrase N-terminal SAM-like domain-containing protein | - |
TRAD_RS07075 | 1528633..1530336 | + | 1704 | WP_041947185.1 | hypothetical protein | - |
TRAD_RS07080 | 1530469..1530762 | + | 294 | WP_013177919.1 | DUF2442 domain-containing protein | - |
TRAD_RS07085 | 1530755..1531015 | + | 261 | WP_013177920.1 | DUF4160 domain-containing protein | - |
TRAD_RS07090 | 1531196..1531477 | + | 282 | WP_041947734.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
TRAD_RS07095 | 1531493..1531801 | + | 309 | WP_013177922.1 | HigA family addiction module antidote protein | Antitoxin |
TRAD_RS07100 | 1531959..1532228 | + | 270 | WP_013177923.1 | DUF2568 domain-containing protein | - |
TRAD_RS07105 | 1532736..1533635 | + | 900 | WP_013177924.1 | PhzF family phenazine biosynthesis protein | - |
TRAD_RS07110 | 1533628..1534353 | + | 726 | WP_013177925.1 | rRNA pseudouridine synthase | - |
TRAD_RS07115 | 1534364..1534915 | + | 552 | WP_041947735.1 | hypoxanthine phosphoribosyltransferase | - |
TRAD_RS16015 | 1535435..1536064 | + | 630 | WP_185095217.1 | M23 family metallopeptidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 1526083..1526511 | 428 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 11062.51 Da Isoelectric Point: 9.8735
>T24788 WP_041947734.1 NC_014221:1531196-1531477 [Truepera radiovictrix DSM 17093]
VIKSFRDQEAQKVFSRQRSRKLPQDIQQVAYRKLRMLSNAQTLADLRIPPANRLEKLSGNRAGEYSIRINDQWRICFEWH
DGDAYNVEIVDYH
VIKSFRDQEAQKVFSRQRSRKLPQDIQQVAYRKLRMLSNAQTLADLRIPPANRLEKLSGNRAGEYSIRINDQWRICFEWH
DGDAYNVEIVDYH
Download Length: 282 bp
>T24788 NC_014221:1531196-1531477 [Truepera radiovictrix DSM 17093]
GTGATCAAGTCCTTCAGGGATCAGGAAGCCCAAAAGGTCTTCTCCCGCCAGCGCTCGCGGAAACTCCCGCAGGACATTCA
ACAAGTCGCCTATCGAAAGCTTCGCATGCTTAGCAACGCCCAAACGCTTGCTGACCTACGTATCCCCCCTGCCAACCGAC
TCGAAAAGCTAAGTGGTAACCGAGCAGGAGAGTACAGCATCCGCATCAACGATCAGTGGCGTATCTGCTTTGAGTGGCAT
GACGGTGACGCTTACAACGTTGAAATTGTGGATTATCATTAG
GTGATCAAGTCCTTCAGGGATCAGGAAGCCCAAAAGGTCTTCTCCCGCCAGCGCTCGCGGAAACTCCCGCAGGACATTCA
ACAAGTCGCCTATCGAAAGCTTCGCATGCTTAGCAACGCCCAAACGCTTGCTGACCTACGTATCCCCCCTGCCAACCGAC
TCGAAAAGCTAAGTGGTAACCGAGCAGGAGAGTACAGCATCCGCATCAACGATCAGTGGCGTATCTGCTTTGAGTGGCAT
GACGGTGACGCTTACAACGTTGAAATTGTGGATTATCATTAG
Antitoxin
Download Length: 103 a.a. Molecular weight: 11406.11 Da Isoelectric Point: 5.5694
>AT24788 WP_013177922.1 NC_014221:1531493-1531801 [Truepera radiovictrix DSM 17093]
MSEEKLAPVHPGEVLLEEFLKPMEISQNRLALSIGVPARRINEIVLGKRGITADTALRLARFFGTSPQFWLGLQTDYDLD
VTLDMLGDRLEREVHAVHASHG
MSEEKLAPVHPGEVLLEEFLKPMEISQNRLALSIGVPARRINEIVLGKRGITADTALRLARFFGTSPQFWLGLQTDYDLD
VTLDMLGDRLEREVHAVHASHG
Download Length: 309 bp
>AT24788 NC_014221:1531493-1531801 [Truepera radiovictrix DSM 17093]
ATGAGTGAAGAAAAGCTCGCACCTGTACATCCTGGCGAGGTCCTCTTAGAGGAGTTTTTGAAGCCTATGGAGATCAGCCA
GAATCGCCTGGCGCTCAGTATCGGCGTGCCGGCGCGGCGGATCAACGAGATCGTTCTCGGTAAGCGCGGTATCACCGCGG
ATACTGCGTTGAGACTTGCCCGCTTTTTTGGGACGTCGCCTCAGTTCTGGCTGGGGCTCCAGACGGATTATGACCTCGAT
GTGACGTTAGACATGCTTGGTGACAGGCTCGAGCGCGAAGTACACGCTGTTCACGCAAGTCACGGATAA
ATGAGTGAAGAAAAGCTCGCACCTGTACATCCTGGCGAGGTCCTCTTAGAGGAGTTTTTGAAGCCTATGGAGATCAGCCA
GAATCGCCTGGCGCTCAGTATCGGCGTGCCGGCGCGGCGGATCAACGAGATCGTTCTCGGTAAGCGCGGTATCACCGCGG
ATACTGCGTTGAGACTTGCCCGCTTTTTTGGGACGTCGCCTCAGTTCTGGCTGGGGCTCCAGACGGATTATGACCTCGAT
GTGACGTTAGACATGCTTGGTGACAGGCTCGAGCGCGAAGTACACGCTGTTCACGCAAGTCACGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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