Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1531196..1531801 Replicon chromosome
Accession NC_014221
Organism Truepera radiovictrix DSM 17093

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag TRAD_RS07090 Protein ID WP_041947734.1
Coordinates 1531196..1531477 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag TRAD_RS07095 Protein ID WP_013177922.1
Coordinates 1531493..1531801 (+) Length 103 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TRAD_RS16315 1526691..1526855 - 165 WP_013177915.1 hypothetical protein -
TRAD_RS07070 1526997..1527650 + 654 WP_148221311.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
TRAD_RS15685 1528035..1528448 - 414 WP_083770752.1 phage integrase N-terminal SAM-like domain-containing protein -
TRAD_RS07075 1528633..1530336 + 1704 WP_041947185.1 hypothetical protein -
TRAD_RS07080 1530469..1530762 + 294 WP_013177919.1 DUF2442 domain-containing protein -
TRAD_RS07085 1530755..1531015 + 261 WP_013177920.1 DUF4160 domain-containing protein -
TRAD_RS07090 1531196..1531477 + 282 WP_041947734.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TRAD_RS07095 1531493..1531801 + 309 WP_013177922.1 HigA family addiction module antidote protein Antitoxin
TRAD_RS07100 1531959..1532228 + 270 WP_013177923.1 DUF2568 domain-containing protein -
TRAD_RS07105 1532736..1533635 + 900 WP_013177924.1 PhzF family phenazine biosynthesis protein -
TRAD_RS07110 1533628..1534353 + 726 WP_013177925.1 rRNA pseudouridine synthase -
TRAD_RS07115 1534364..1534915 + 552 WP_041947735.1 hypoxanthine phosphoribosyltransferase -
TRAD_RS16015 1535435..1536064 + 630 WP_185095217.1 M23 family metallopeptidase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1526083..1526511 428


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-93)

Antitoxin

(1-92)


Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 11062.51 Da        Isoelectric Point: 9.8735

>T24788 WP_041947734.1 NC_014221:1531196-1531477 [Truepera radiovictrix DSM 17093]
VIKSFRDQEAQKVFSRQRSRKLPQDIQQVAYRKLRMLSNAQTLADLRIPPANRLEKLSGNRAGEYSIRINDQWRICFEWH
DGDAYNVEIVDYH

Download         Length: 282 bp

>T24788 NC_014221:1531196-1531477 [Truepera radiovictrix DSM 17093]
GTGATCAAGTCCTTCAGGGATCAGGAAGCCCAAAAGGTCTTCTCCCGCCAGCGCTCGCGGAAACTCCCGCAGGACATTCA
ACAAGTCGCCTATCGAAAGCTTCGCATGCTTAGCAACGCCCAAACGCTTGCTGACCTACGTATCCCCCCTGCCAACCGAC
TCGAAAAGCTAAGTGGTAACCGAGCAGGAGAGTACAGCATCCGCATCAACGATCAGTGGCGTATCTGCTTTGAGTGGCAT
GACGGTGACGCTTACAACGTTGAAATTGTGGATTATCATTAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11406.11 Da        Isoelectric Point: 5.5694

>AT24788 WP_013177922.1 NC_014221:1531493-1531801 [Truepera radiovictrix DSM 17093]
MSEEKLAPVHPGEVLLEEFLKPMEISQNRLALSIGVPARRINEIVLGKRGITADTALRLARFFGTSPQFWLGLQTDYDLD
VTLDMLGDRLEREVHAVHASHG

Download         Length: 309 bp

>AT24788 NC_014221:1531493-1531801 [Truepera radiovictrix DSM 17093]
ATGAGTGAAGAAAAGCTCGCACCTGTACATCCTGGCGAGGTCCTCTTAGAGGAGTTTTTGAAGCCTATGGAGATCAGCCA
GAATCGCCTGGCGCTCAGTATCGGCGTGCCGGCGCGGCGGATCAACGAGATCGTTCTCGGTAAGCGCGGTATCACCGCGG
ATACTGCGTTGAGACTTGCCCGCTTTTTTGGGACGTCGCCTCAGTTCTGGCTGGGGCTCCAGACGGATTATGACCTCGAT
GTGACGTTAGACATGCTTGGTGACAGGCTCGAGCGCGAAGTACACGCTGTTCACGCAAGTCACGGATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References