Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 64694..65359 Replicon plasmid pYR4
Accession NZ_CP098712
Organism Yersinia ruckeri strain NVI-1292

Toxin (Protein)


Gene name higB Uniprot ID A0A380S9H4
Locus tag ND448_RS17400 Protein ID WP_038251855.1
Coordinates 65036..65359 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ND448_RS17395 Protein ID WP_004720859.1
Coordinates 64694..64990 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND448_RS17375 (ND448_17370) 59991..61916 - 1926 WP_004720847.1 relaxase/mobilization nuclease domain-containing protein -
ND448_RS17380 (ND448_17375) 61918..62262 - 345 WP_004720848.1 plasmid mobilization protein MobA -
ND448_RS17385 (ND448_17380) 62531..62854 + 324 WP_004720850.1 hypothetical protein -
ND448_RS17390 (ND448_17385) 63393..64206 - 814 Protein_61 DUF932 domain-containing protein -
ND448_RS17395 (ND448_17390) 64694..64990 - 297 WP_004720859.1 NadS family protein Antitoxin
ND448_RS17400 (ND448_17395) 65036..65359 - 324 WP_038251855.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ND448_RS17405 (ND448_17400) 65511..65744 + 234 WP_038251853.1 hypothetical protein -
ND448_RS17410 (ND448_17405) 65752..66249 - 498 WP_126940174.1 hypothetical protein -
ND448_RS17415 (ND448_17410) 66246..66605 - 360 WP_126940175.1 DUF3085 domain-containing protein -
ND448_RS17420 (ND448_17415) 67364..68176 - 813 WP_238692894.1 N-6 DNA methylase -
ND448_RS17425 (ND448_17420) 68220..68366 - 147 WP_126940177.1 succinate dehydrogenase flavoprotein subunit -
ND448_RS17430 (ND448_17425) 68452..68808 - 357 WP_126940178.1 hypothetical protein -
ND448_RS17435 (ND448_17430) 69562..69762 - 201 WP_126940179.1 hypothetical protein -
ND448_RS17440 (ND448_17435) 69805..70311 - 507 WP_126940180.1 antirestriction protein ArdA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..80847 80847


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(46-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-82)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12416.31 Da        Isoelectric Point: 8.8371

>T247861 WP_038251855.1 NZ_CP098712:c65359-65036 [Yersinia ruckeri]
MEYLEFIETPVFSRRRAELLPDDDFRALQEHLLKNHDLGDTISKTGGCKKIRWSREGMGKRGGVRVIYYVITKSGRLYLL
LVYPKNEKDDLTEAEKAVLKSISQQIE

Download         Length: 324 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11027.77 Da        Isoelectric Point: 6.7264

>AT247861 WP_004720859.1 NZ_CP098712:c64990-64694 [Yersinia ruckeri]
MKTELFNDLVESMQQMVAIEKGTLSVPAENIHRHRLPDVKSMREASGLKQNEFADVVGVSASLLQSWEQHRRIPSGSSLK
LLMMIERDPAVIDALRTL

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380S9H4

Antitoxin

Source ID Structure

References