Detailed information of TA system TA024782

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3148856..3149440
• Replicon: chromosome
• Accession: NC_014217
• Organism: Starkeya novella DSM 506

Toxin (Protein)

• Gene name: higB
• Uniprot ID: D7A759
• Locus tag: SNOV_RS14950
• Protein ID: WP_013167793.1
• Coordinates: 3149159..3149440 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: SNOV_RS14945
• Protein ID: WP_013167792.1
• Coordinates: 3148856..3149149 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SNOV_RS14925	3145133..3145696	+	564	WP_041783443.1	sarcosine oxidase subunit gamma family protein	-
SNOV_RS14930	3145836..3147200	+	1365	WP_013167789.1	L-serine ammonia-lyase	-
SNOV_RS14935	3147284..3148339	+	1056	WP_013167790.1	GlxA family transcriptional regulator	-
SNOV_RS14940	3148346..3148783	-	438	WP_013167791.1	EamA family transporter	-
SNOV_RS14945	3148856..3149149	-	294	WP_013167792.1	HigA family addiction module antidote protein	Antitoxin
SNOV_RS14950	3149159..3149440	-	282	WP_013167793.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SNOV_RS14955	3149614..3150873	+	1260	WP_013167794.1	aromatic ring-hydroxylating dioxygenase subunit alpha	-
SNOV_RS14960	3150876..3152042	+	1167	WP_013167795.1	hybrid-cluster NAD(P)-dependent oxidoreductase	-
SNOV_RS14965	3152112..3152801	-	690	WP_013167796.1	hypothetical protein	-
SNOV_RS14970	3152925..3153896	+	972	WP_013167797.1	GlxA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-85)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10498.05 Da
• Isoelectric Point: 9.7585

>T24782 WP_013167793.1 NC_014217:c3149440-3149159 [Starkeya novella DSM 506]
VILNFKDKRTEAVWSGTIGKGFPPDLMRTAQRKLAMLNAAVGLDALRVPPSNRLEALKGDRVGQYSIRINDQFRLCFVWR
DGHAGDVEITDYH

Nucleotide

• Length: 282 bp

>T24782 NC_014217:c3149440-3149159 [Starkeya novella DSM 506]
GTGATCCTGAACTTCAAGGACAAGCGCACGGAAGCGGTGTGGAGCGGCACCATCGGCAAAGGGTTTCCGCCCGACCTGAT
GCGGACGGCGCAGCGCAAGCTGGCGATGCTGAACGCTGCGGTCGGGCTCGATGCGTTGCGGGTTCCACCGTCCAACCGGC
TGGAGGCATTGAAGGGCGATCGCGTGGGTCAATATTCGATCCGCATCAACGACCAGTTCCGCCTCTGCTTCGTCTGGCGC
GACGGCCATGCCGGCGATGTCGAGATCACGGACTATCACTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10548.26 Da
• Isoelectric Point: 7.0117

>AT24782 WP_013167792.1 NC_014217:c3149149-3148856 [Starkeya novella DSM 506]
MLGPNPPVHPGEILREEFLLPLALTPYGVARALGVPRTRIERLAREETPVTADTALRLGRYFGTGPEFWMNLQTNFDLAA
TAAKLPELAAIAPVRAA

Nucleotide

• Length: 294 bp

>AT24782 NC_014217:c3149149-3148856 [Starkeya novella DSM 506]
ATGCTCGGTCCCAACCCTCCAGTCCATCCCGGCGAGATCCTCCGCGAGGAATTCCTGTTGCCTCTCGCGCTCACGCCCTA
TGGGGTCGCGCGGGCGCTCGGCGTGCCGCGTACCCGGATCGAGCGGCTGGCGCGGGAGGAGACGCCGGTGACCGCAGATA
CCGCGCTGCGGCTGGGGCGCTATTTCGGCACCGGGCCGGAATTCTGGATGAACCTGCAGACGAATTTCGATCTTGCCGCC
ACCGCGGCGAAGCTGCCGGAGCTCGCCGCCATCGCGCCTGTGCGCGCAGCCTGA

Structures

Toxin

• AlphaFold DB: D7A759