Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3148856..3149440 Replicon chromosome
Accession NC_014217
Organism Starkeya novella DSM 506

Toxin (Protein)


Gene name higB Uniprot ID D7A759
Locus tag SNOV_RS14950 Protein ID WP_013167793.1
Coordinates 3149159..3149440 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SNOV_RS14945 Protein ID WP_013167792.1
Coordinates 3148856..3149149 (-) Length 98 a.a.

Genomic Context

SNOV_RS14925SNOV_RS14930SNOV_RS14935SNOV_RS14955SNOV_RS14960SNOV_RS14970SNOV_RS14940SNOV_RS14945SNOV_RS14950SNOV_RS14965
Location: 3145133..3145696 (564 bp)
Type: Others
Protein ID: WP_041783443.1
Location: 3145836..3147200 (1365 bp)
Type: Others
Protein ID: WP_013167789.1
Location: 3147284..3148339 (1056 bp)
Type: Others
Protein ID: WP_013167790.1
Location: 3149614..3150873 (1260 bp)
Type: Others
Protein ID: WP_013167794.1
Location: 3150876..3152042 (1167 bp)
Type: Others
Protein ID: WP_013167795.1
Location: 3152925..3153896 (972 bp)
Type: Others
Protein ID: WP_013167797.1
Location: 3148346..3148783 (438 bp)
Type: Others
Protein ID: WP_013167791.1
Location: 3148856..3149149 (294 bp)
Type: Antitoxin
Protein ID: WP_013167792.1
Location: 3149159..3149440 (282 bp)
Type: Toxin
Protein ID: WP_013167793.1
Location: 3152112..3152801 (690 bp)
Type: Others
Protein ID: WP_013167796.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SNOV_RS149253145133..3145696+564WP_041783443.1sarcosine oxidase subunit gamma family protein-
SNOV_RS149303145836..3147200+1365WP_013167789.1L-serine ammonia-lyase-
SNOV_RS149353147284..3148339+1056WP_013167790.1GlxA family transcriptional regulator-
SNOV_RS149403148346..3148783-438WP_013167791.1EamA family transporter-
SNOV_RS149453148856..3149149-294WP_013167792.1HigA family addiction module antidote proteinAntitoxin
SNOV_RS149503149159..3149440-282WP_013167793.1type II toxin-antitoxin system RelE/ParE family toxinToxin
SNOV_RS149553149614..3150873+1260WP_013167794.1aromatic ring-hydroxylating dioxygenase subunit alpha-
SNOV_RS149603150876..3152042+1167WP_013167795.1hybrid-cluster NAD(P)-dependent oxidoreductase-
SNOV_RS149653152112..3152801-690WP_013167796.1hypothetical protein-
SNOV_RS149703152925..3153896+972WP_013167797.1GlxA family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-85)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10498.05 Da        Isoelectric Point: 9.7585

>T24782 WP_013167793.1 NC_014217:c3149440-3149159 [Starkeya novella DSM 506]
VILNFKDKRTEAVWSGTIGKGFPPDLMRTAQRKLAMLNAAVGLDALRVPPSNRLEALKGDRVGQYSIRINDQFRLCFVWR
DGHAGDVEITDYH

Download         Length: 282 bp

>T24782 NC_014217:c3149440-3149159 [Starkeya novella DSM 506]
GTGATCCTGAACTTCAAGGACAAGCGCACGGAAGCGGTGTGGAGCGGCACCATCGGCAAAGGGTTTCCGCCCGACCTGAT
GCGGACGGCGCAGCGCAAGCTGGCGATGCTGAACGCTGCGGTCGGGCTCGATGCGTTGCGGGTTCCACCGTCCAACCGGC
TGGAGGCATTGAAGGGCGATCGCGTGGGTCAATATTCGATCCGCATCAACGACCAGTTCCGCCTCTGCTTCGTCTGGCGC
GACGGCCATGCCGGCGATGTCGAGATCACGGACTATCACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10548.26 Da        Isoelectric Point: 7.0117

>AT24782 WP_013167792.1 NC_014217:c3149149-3148856 [Starkeya novella DSM 506]
MLGPNPPVHPGEILREEFLLPLALTPYGVARALGVPRTRIERLAREETPVTADTALRLGRYFGTGPEFWMNLQTNFDLAA
TAAKLPELAAIAPVRAA

Download         Length: 294 bp

>AT24782 NC_014217:c3149149-3148856 [Starkeya novella DSM 506]
ATGCTCGGTCCCAACCCTCCAGTCCATCCCGGCGAGATCCTCCGCGAGGAATTCCTGTTGCCTCTCGCGCTCACGCCCTA
TGGGGTCGCGCGGGCGCTCGGCGTGCCGCGTACCCGGATCGAGCGGCTGGCGCGGGAGGAGACGCCGGTGACCGCAGATA
CCGCGCTGCGGCTGGGGCGCTATTTCGGCACCGGGCCGGAATTCTGGATGAACCTGCAGACGAATTTCGATCTTGCCGCC
ACCGCGGCGAAGCTGCCGGAGCTCGCCGCCATCGCGCCTGTGCGCGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBD7A759

Antitoxin

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Source
ID
Structure
No matching records found

References