247817

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 19059..19690 Replicon plasmid pYR10
Accession NZ_CP098702
Organism Yersinia ruckeri strain NVI-5089

Toxin (Protein)


Gene name higB Uniprot ID A0A2R4NX45
Locus tag ND440_RS17280 Protein ID WP_049615238.1
Coordinates 19059..19349 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ND440_RS17285 Protein ID WP_049615233.1
Coordinates 19361..19690 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND440_RS17255 (ND440_17250) 14649..15269 + 621 WP_226723006.1 ParA family protein -
ND440_RS17260 (ND440_17255) 15319..15546 + 228 WP_145544398.1 hypothetical protein -
ND440_RS17265 (ND440_17260) 16045..17301 - 1257 WP_234049633.1 translesion error-prone DNA polymerase V subunit UmuC -
ND440_RS17270 (ND440_17265) 17301..17726 - 426 WP_234049632.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
ND440_RS17275 (ND440_17270) 18100..18921 + 822 WP_080991164.1 N-6 DNA methylase -
ND440_RS17280 (ND440_17275) 19059..19349 + 291 WP_049615238.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ND440_RS17285 (ND440_17280) 19361..19690 + 330 WP_049615233.1 HigA family addiction module antitoxin Antitoxin
ND440_RS17290 (ND440_17285) 20112..20612 + 501 WP_265317717.1 hypothetical protein -
ND440_RS17295 (ND440_17290) 20869..21846 + 978 WP_234049631.1 plasmid segregation protein ParM -
ND440_RS17300 (ND440_17295) 21853..22257 + 405 WP_265317718.1 plasmid partitioning/stability family protein -
ND440_RS17305 (ND440_17300) 22356..22919 + 564 WP_234049629.1 helix-turn-helix transcriptional regulator -
ND440_RS17310 (ND440_17305) 23227..23463 + 237 WP_073999971.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..89273 89273


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-85)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11538.18 Da        Isoelectric Point: 9.3579

>T247817 WP_049615238.1 NZ_CP098702:19059-19349 [Yersinia ruckeri]
MIKSFRDKNLELFYMESKRDRAIPATIERQLAKKLDMLAAAHNERDLFIPTSNYYKRLSGQFDGWSSMRVNIQWRLMFQW
KDGYAESIYLDPHQDT

Download         Length: 291 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12630.54 Da        Isoelectric Point: 6.2374

>AT247817 WP_049615233.1 NZ_CP098702:19361-19690 [Yersinia ruckeri]
MLDTTTREPTTVGEILQEEFLTPLAIGQEELADIMGVTRATVNRLCKGRRRLTVEEATLFSELFETTPEFWLNLQAAHDR
WEAREALQKHKRPPMRPIMEMLGRRISHA

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R4NX45

Antitoxin

Source ID Structure

References