Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 51385..52050 Replicon plasmid pYR4
Accession NZ_CP098699
Organism Yersinia ruckeri strain NVI-6614

Toxin (Protein)


Gene name higB Uniprot ID A0A380S9H4
Locus tag ND449_RS17800 Protein ID WP_038251855.1
Coordinates 51727..52050 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ND449_RS17795 Protein ID WP_004720859.1
Coordinates 51385..51681 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND449_RS17775 (ND449_17760) 46682..48607 - 1926 WP_004720847.1 relaxase/mobilization nuclease domain-containing protein -
ND449_RS17780 (ND449_17765) 48609..48953 - 345 WP_004720848.1 plasmid mobilization protein MobA -
ND449_RS17785 (ND449_17770) 49222..49545 + 324 WP_004720850.1 hypothetical protein -
ND449_RS17790 (ND449_17780) 50084..50897 - 814 Protein_46 DUF932 domain-containing protein -
ND449_RS17795 (ND449_17785) 51385..51681 - 297 WP_004720859.1 NadS family protein Antitoxin
ND449_RS17800 (ND449_17790) 51727..52050 - 324 WP_038251855.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ND449_RS17805 (ND449_17795) 52202..52435 + 234 WP_038251853.1 hypothetical protein -
ND449_RS17810 (ND449_17800) 52443..52940 - 498 WP_126940174.1 hypothetical protein -
ND449_RS17815 (ND449_17805) 52937..53296 - 360 WP_126940175.1 DUF3085 domain-containing protein -
ND449_RS17820 (ND449_17810) 54055..54765 - 711 WP_126940176.1 N-6 DNA methylase -
ND449_RS17825 (ND449_17815) 54911..55057 - 147 WP_126940177.1 succinate dehydrogenase flavoprotein subunit -
ND449_RS17830 (ND449_17820) 55143..55499 - 357 WP_126940178.1 hypothetical protein -
ND449_RS17835 (ND449_17825) 56253..56453 - 201 WP_126940179.1 hypothetical protein -
ND449_RS17840 (ND449_17830) 56496..57002 - 507 WP_126940180.1 antirestriction protein ArdA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..80438 80438


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(46-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-82)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12416.31 Da        Isoelectric Point: 8.8371

>T247805 WP_038251855.1 NZ_CP098699:c52050-51727 [Yersinia ruckeri]
MEYLEFIETPVFSRRRAELLPDDDFRALQEHLLKNHDLGDTISKTGGCKKIRWSREGMGKRGGVRVIYYVITKSGRLYLL
LVYPKNEKDDLTEAEKAVLKSISQQIE

Download         Length: 324 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11027.77 Da        Isoelectric Point: 6.7264

>AT247805 WP_004720859.1 NZ_CP098699:c51681-51385 [Yersinia ruckeri]
MKTELFNDLVESMQQMVAIEKGTLSVPAENIHRHRLPDVKSMREASGLKQNEFADVVGVSASLLQSWEQHRRIPSGSSLK
LLMMIERDPAVIDALRTL

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380S9H4

Antitoxin

Source ID Structure

References