Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 22916..23547 Replicon plasmid pYR6
Accession NZ_CP098698
Organism Yersinia ruckeri strain NVI-6614

Toxin (Protein)


Gene name higB Uniprot ID A0A2R4NX45
Locus tag ND449_RS17240 Protein ID WP_049615238.1
Coordinates 22916..23206 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ND449_RS17245 Protein ID WP_049615233.1
Coordinates 23218..23547 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND449_RS17220 (ND449_17205) 19488..20777 - 1290 WP_267257518.1 site-specific integrase -
ND449_RS17225 (ND449_17210) 20796..21158 - 363 WP_267257519.1 hypothetical protein -
ND449_RS17230 (ND449_17215) 21158..21583 - 426 WP_267257520.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
ND449_RS17235 (ND449_17220) 21957..22778 + 822 WP_080991164.1 N-6 DNA methylase -
ND449_RS17240 (ND449_17225) 22916..23206 + 291 WP_049615238.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ND449_RS17245 (ND449_17230) 23218..23547 + 330 WP_049615233.1 HigA family addiction module antitoxin Antitoxin
ND449_RS17250 (ND449_17235) 23969..24469 + 501 WP_265317717.1 hypothetical protein -
ND449_RS17255 (ND449_17240) 24726..25703 + 978 WP_267257521.1 plasmid segregation protein ParM -
ND449_RS17260 (ND449_17245) 25710..26114 + 405 WP_234049630.1 plasmid partitioning/stability family protein -
ND449_RS17265 (ND449_17250) 26213..26776 + 564 WP_234049629.1 helix-turn-helix transcriptional regulator -
ND449_RS17270 (ND449_17255) 27084..27320 + 237 WP_073999971.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..83000 83000


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-85)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11538.18 Da        Isoelectric Point: 9.3579

>T247804 WP_049615238.1 NZ_CP098698:22916-23206 [Yersinia ruckeri]
MIKSFRDKNLELFYMESKRDRAIPATIERQLAKKLDMLAAAHNERDLFIPTSNYYKRLSGQFDGWSSMRVNIQWRLMFQW
KDGYAESIYLDPHQDT

Download         Length: 291 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12630.54 Da        Isoelectric Point: 6.2374

>AT247804 WP_049615233.1 NZ_CP098698:23218-23547 [Yersinia ruckeri]
MLDTTTREPTTVGEILQEEFLTPLAIGQEELADIMGVTRATVNRLCKGRRRLTVEEATLFSELFETTPEFWLNLQAAHDR
WEAREALQKHKRPPMRPIMEMLGRRISHA

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R4NX45

Antitoxin

Source ID Structure

References