Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 12721..13386 Replicon plasmid pYR4
Accession NZ_CP098696
Organism Yersinia ruckeri strain NVI-701

Toxin (Protein)


Gene name higB Uniprot ID A0A380S9H4
Locus tag ND443_RS17125 Protein ID WP_038251855.1
Coordinates 12721..13044 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ND443_RS17130 Protein ID WP_004720859.1
Coordinates 13090..13386 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ND443_RS17085 (ND443_17075) 7769..8275 + 507 WP_126940180.1 antirestriction protein ArdA -
ND443_RS17090 (ND443_17080) 8318..8518 + 201 WP_126940179.1 hypothetical protein -
ND443_RS17095 (ND443_17085) 9272..9628 + 357 WP_126940178.1 hypothetical protein -
ND443_RS17100 (ND443_17090) 9714..9860 + 147 WP_126940177.1 succinate dehydrogenase flavoprotein subunit -
ND443_RS17105 (ND443_17095) 9904..10716 + 813 WP_238692894.1 N-6 DNA methylase -
ND443_RS17110 (ND443_17100) 11475..11834 + 360 WP_126940175.1 DUF3085 domain-containing protein -
ND443_RS17115 (ND443_17105) 11831..12328 + 498 WP_126940174.1 hypothetical protein -
ND443_RS17120 (ND443_17110) 12336..12569 - 234 WP_038251853.1 hypothetical protein -
ND443_RS17125 (ND443_17115) 12721..13044 + 324 WP_038251855.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ND443_RS17130 (ND443_17120) 13090..13386 + 297 WP_004720859.1 NadS family protein Antitoxin
ND443_RS17135 (ND443_17125) 13874..14687 + 814 Protein_19 DUF932 domain-containing protein -
ND443_RS17140 (ND443_17130) 15226..15549 - 324 WP_004720850.1 hypothetical protein -
ND443_RS17145 (ND443_17135) 15818..16162 + 345 WP_004720848.1 plasmid mobilization protein MobA -
ND443_RS17150 (ND443_17140) 16164..18089 + 1926 WP_004720847.1 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..80847 80847


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(46-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-82)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12416.31 Da        Isoelectric Point: 8.8371

>T247793 WP_038251855.1 NZ_CP098696:12721-13044 [Yersinia ruckeri]
MEYLEFIETPVFSRRRAELLPDDDFRALQEHLLKNHDLGDTISKTGGCKKIRWSREGMGKRGGVRVIYYVITKSGRLYLL
LVYPKNEKDDLTEAEKAVLKSISQQIE

Download         Length: 324 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11027.77 Da        Isoelectric Point: 6.7264

>AT247793 WP_004720859.1 NZ_CP098696:13090-13386 [Yersinia ruckeri]
MKTELFNDLVESMQQMVAIEKGTLSVPAENIHRHRLPDVKSMREASGLKQNEFADVVGVSASLLQSWEQHRRIPSGSSLK
LLMMIERDPAVIDALRTL

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380S9H4

Antitoxin

Source ID Structure

References