Detailed information of TA system TA024779

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-MqsA
• Location: 1216716..1217301
• Replicon: chromosome
• Accession: NC_014216
• Organism: Desulfurivibrio alkaliphilus AHT2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: DAAHT2_RS05180
• Protein ID: WP_013163244.1
• Coordinates: 1216996..1217301 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DAAHT2_RS05175
• Protein ID: WP_013163243.1
• Coordinates: 1216716..1217003 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAAHT2_RS05165	1212188..1212655	-	468	WP_157861420.1	hypothetical protein	-
DAAHT2_RS14250	1212795..1214072	-	1278	WP_013163240.1	reverse transcriptase/maturase family protein	-
DAAHT2_RS14620	1214480..1215187	-	708	WP_013163242.1	hypothetical protein	-
DAAHT2_RS05170	1215678..1216289	-	612	Protein_1016	Fic family protein	-
DAAHT2_RS05175	1216716..1217003	-	288	WP_013163243.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
DAAHT2_RS05180	1216996..1217301	-	306	WP_013163244.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DAAHT2_RS05185	1217483..1217755	-	273	WP_013163245.1	hypothetical protein	-
DAAHT2_RS14855	1217815..1218042	+	228	WP_174259450.1	hypothetical protein	-
DAAHT2_RS05195	1218112..1218339	+	228	WP_013163246.1	rubredoxin	-
DAAHT2_RS14260	1218406..1218678	+	273	WP_013163247.1	hypothetical protein	-
DAAHT2_RS05205	1218767..1219693	+	927	WP_013163248.1	patatin-like phospholipase family protein	-
DAAHT2_RS05210	1219834..1220943	+	1110	WP_013163249.1	MipA/OmpV family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-95)

Antitoxin

• Antitoxin MqsA/HigA-2 (34-94)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11371.04 Da
• Isoelectric Point: 9.7632

>T24779 WP_013163244.1 NC_014216:c1217301-1216996 [Desulfurivibrio alkaliphilus AHT 2]
IYETSIFTKLLRNYLSDEEYCGLQTYLLQKPDAGDLIKGSGGVRKVRWASAGTGKSGGLRVIYYWKKSDHEIWMLTLYSK
SERASIPGHTLKQIAEAIKNG

Nucleotide

• Length: 306 bp

>T24779 NC_014216:c1217301-1216996 [Desulfurivibrio alkaliphilus AHT 2]
ATTTATGAAACATCGATTTTTACCAAGCTGTTGCGCAACTACCTCTCGGACGAGGAATATTGTGGGCTGCAAACCTATCT
ATTGCAGAAGCCGGATGCTGGCGATCTCATCAAGGGATCAGGTGGTGTTCGCAAGGTTCGATGGGCGTCGGCGGGTACGG
GAAAGAGCGGTGGCCTCAGGGTGATTTATTACTGGAAAAAATCTGACCACGAGATATGGATGCTCACACTTTACAGTAAA
TCGGAGCGGGCCAGTATTCCCGGGCATACGCTCAAGCAGATAGCGGAGGCAATCAAAAATGGCTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10631.42 Da
• Isoelectric Point: 10.6470

>AT24779 WP_013163243.1 NC_014216:c1217003-1216716 [Desulfurivibrio alkaliphilus AHT 2]
MADRNLGAEILDGINEIKRFKKGKLELRTHELSAPSPPKVIRLKLKMSQSAFAGLMGVSVRTLQDWEQGRREPQGPAVAL
LRIVEQHPEVLGQLH

Nucleotide

• Length: 288 bp

>AT24779 NC_014216:c1217003-1216716 [Desulfurivibrio alkaliphilus AHT 2]
ATGGCTGACAGGAACCTTGGAGCAGAAATCCTTGACGGTATCAATGAGATTAAGCGGTTCAAGAAAGGCAAACTGGAACT
GCGGACCCATGAACTTTCAGCACCGTCTCCACCCAAGGTGATTCGGCTGAAATTAAAGATGTCGCAATCGGCTTTTGCCG
GTCTCATGGGAGTAAGCGTGCGGACCCTTCAGGACTGGGAGCAGGGGCGGCGGGAACCGCAAGGCCCGGCGGTTGCGCTC
TTGCGTATTGTAGAGCAACACCCGGAAGTGCTTGGCCAGCTTCACTGA