Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4893168..4893676 Replicon chromosome
Accession NZ_CP098609
Organism Streptomyces filamentosus strain L30

Toxin (Protein)


Gene name yoeB Uniprot ID V6U5B2
Locus tag K7395_RS21700 Protein ID WP_006125194.1
Coordinates 4893168..4893428 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID V6U6C9
Locus tag K7395_RS21705 Protein ID WP_006125193.1
Coordinates 4893425..4893676 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7395_RS21680 (K7395_21680) 4888625..4889950 + 1326 WP_006125198.1 resuscitation-promoting factor -
K7395_RS21685 (K7395_21685) 4889947..4890822 + 876 WP_006125197.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
K7395_RS21690 (K7395_21690) 4890828..4891727 + 900 WP_006125196.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
K7395_RS21695 (K7395_21695) 4891809..4893164 + 1356 WP_006125195.1 acyltransferase -
K7395_RS21700 (K7395_21700) 4893168..4893428 - 261 WP_006125194.1 Txe/YoeB family addiction module toxin Toxin
K7395_RS21705 (K7395_21705) 4893425..4893676 - 252 WP_006125193.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
K7395_RS21710 (K7395_21710) 4893872..4894285 - 414 WP_006125192.1 hypothetical protein -
K7395_RS21715 (K7395_21715) 4894316..4894891 - 576 WP_010071045.1 hypothetical protein -
K7395_RS21720 (K7395_21720) 4895098..4896327 - 1230 WP_252096536.1 histidine kinase -
K7395_RS21725 (K7395_21725) 4896324..4897028 - 705 WP_006125189.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10424.76 Da        Isoelectric Point: 8.5097

>T247749 WP_006125194.1 NZ_CP098609:c4893428-4893168 [Streptomyces filamentosus]
VKFVWDQSSWDDYVWWQNQDRKILRRINTLLQDIARNGNEGMGKPEPLKHGFHGYWSRRITDEHRLICKVVDDEVRIAAC
RYHYGH

Download         Length: 261 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9272.34 Da        Isoelectric Point: 4.4118

>AT247749 WP_006125193.1 NZ_CP098609:c4893676-4893425 [Streptomyces filamentosus]
MRTMTYTESRAKYAETLSAVVDDREEVVVTRAGHEPVVIVALDEYESLKETAYQLRSPENARRLLASIDRLESGGGTVQE
LAE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6U5B2

Antitoxin

Source ID Structure
AlphaFold DB V6U6C9

References