Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2347393..2347982 Replicon chromosome
Accession NZ_CP098604
Organism Xanthomonas hortorum pv. pelargonii strain OSU493

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag NDY25_RS10345 Protein ID WP_168959041.1
Coordinates 2347701..2347982 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NDY25_RS10340 Protein ID WP_168959042.1
Coordinates 2347393..2347683 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDY25_RS10310 (NDY25_10290) 2342571..2342903 + 333 WP_168959046.1 hypothetical protein -
NDY25_RS10315 (NDY25_10295) 2343018..2344172 - 1155 WP_233366566.1 hypothetical protein -
NDY25_RS10320 (NDY25_10300) 2344207..2344614 - 408 WP_168959045.1 hypothetical protein -
NDY25_RS10325 (NDY25_10305) 2345026..2345216 + 191 Protein_2002 hypothetical protein -
NDY25_RS10330 (NDY25_10310) 2345490..2346308 - 819 WP_218974083.1 AraC family transcriptional regulator -
NDY25_RS10335 (NDY25_10315) 2346527..2347270 + 744 WP_168959043.1 SDR family oxidoreductase -
NDY25_RS10340 (NDY25_10320) 2347393..2347683 - 291 WP_168959042.1 HigA family addiction module antitoxin Antitoxin
NDY25_RS10345 (NDY25_10325) 2347701..2347982 - 282 WP_168959041.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NDY25_RS10350 (NDY25_10330) 2348196..2349251 - 1056 WP_168959040.1 virulence RhuM family protein -
NDY25_RS10355 (NDY25_10335) 2349390..2349677 - 288 WP_256627920.1 ATP-dependent RecD-like DNA helicase -
NDY25_RS10360 (NDY25_10340) 2349761..2351794 - 2034 WP_256627921.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11056.76 Da        Isoelectric Point: 9.7972

>T247746 WP_168959041.1 NZ_CP098604:c2347982-2347701 [Xanthomonas hortorum pv. pelargonii]
MIRSFVDKEAEKIWLGERSRRLPADIQPVARRKLRMLNAAAHLDDLRIPPANRLEALKGERRGQYSIRINDQWRICFRWM
EGDVAEVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10496.19 Da        Isoelectric Point: 7.2043

>AT247746 WP_168959042.1 NZ_CP098604:c2347683-2347393 [Xanthomonas hortorum pv. pelargonii]
MTVLPNIHPGEILLEEFLEPMGISQNALARATAVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLGLQADYELEQA
HRALGDLPSRIKRLAA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References