Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 144370..144955 Replicon plasmid pCl107
Accession NZ_CP098522
Organism Acinetobacter baumannii strain Cl107

Toxin (Protein)


Gene name higB Uniprot ID A0A7S7BY50
Locus tag NDN18_RS20135 Protein ID WP_000897311.1
Coordinates 144370..144690 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NDN18_RS20140 Protein ID WP_255879317.1
Coordinates 144683..144955 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDN18_RS20115 (NDN18_20110) 140176..140505 + 330 WP_000506885.1 DUF4236 domain-containing protein -
NDN18_RS20120 (NDN18_20115) 140777..142009 - 1233 WP_001255535.1 ATP-binding protein -
NDN18_RS20125 (NDN18_20120) 142267..142704 - 438 Protein_130 IS3 family transposase -
NDN18_RS20130 (NDN18_20125) 142781..143692 + 912 WP_195201764.1 IS5-like element IS17 family transposase -
NDN18_RS20135 (NDN18_20130) 144370..144690 + 321 WP_000897311.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NDN18_RS20140 (NDN18_20135) 144683..144955 + 273 WP_255879317.1 NadS family protein Antitoxin
NDN18_RS20145 (NDN18_20140) 145025..146114 - 1090 Protein_134 IS4-like element ISAba1 family transposase -
NDN18_RS20150 (NDN18_20145) 146380..146451 + 72 WP_255879369.1 DUF2971 domain-containing protein -
NDN18_RS20155 (NDN18_20150) 146603..146977 + 375 WP_255879319.1 hypothetical protein -
NDN18_RS20160 (NDN18_20155) 147080..147336 + 257 Protein_137 IS3 family transposase -
NDN18_RS20165 (NDN18_20160) 147484..147696 + 213 WP_001123161.1 hypothetical protein -
NDN18_RS20170 (NDN18_20165) 148022..148879 - 858 WP_000609033.1 LysR family transcriptional regulator -
NDN18_RS20175 (NDN18_20170) 148876..149883 - 1008 WP_005071472.1 phosphonate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul2 / tet(B) / aph(6)-Id / aph(3'')-Ib / aac(3)-IIa / aac(6')-Ian - 1..198716 198716
- inside IScluster/Tn - - 142267..147325 5058


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-84)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12214.03 Da        Isoelectric Point: 7.9500

>T247722 WP_000897311.1 NZ_CP098522:144370-144690 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVTDEEYRQLQQDLLIQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFNG

Download         Length: 321 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10173.62 Da        Isoelectric Point: 7.0146

>AT247722 WP_255879317.1 NZ_CP098522:144683-144955 [Acinetobacter baumannii]
MDNNLFDDLVTSIKEVGAIKRNEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDTNPTLI

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7S7BY50

Antitoxin

Source ID Structure

References