Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4632443..4633045 Replicon chromosome
Accession NZ_CP098486
Organism Enterobacter hormaechei subsp. hormaechei strain ECC33

Toxin (Protein)


Gene name higB Uniprot ID A0A155DUZ6
Locus tag NDJ97_RS22175 Protein ID WP_022649837.1
Coordinates 4632734..4633045 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NDJ97_RS22170 Protein ID WP_022649836.1
Coordinates 4632443..4632733 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDJ97_RS22155 (NDJ97_22150) 4629941..4630843 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
NDJ97_RS22160 (NDJ97_22155) 4630840..4631475 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
NDJ97_RS22165 (NDJ97_22160) 4631472..4632401 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
NDJ97_RS22170 (NDJ97_22165) 4632443..4632733 - 291 WP_022649836.1 NadS family protein Antitoxin
NDJ97_RS22175 (NDJ97_22170) 4632734..4633045 - 312 WP_022649837.1 hypothetical protein Toxin
NDJ97_RS22180 (NDJ97_22175) 4633194..4634135 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
NDJ97_RS22185 (NDJ97_22180) 4634180..4634617 - 438 WP_022649839.1 D-aminoacyl-tRNA deacylase -
NDJ97_RS22190 (NDJ97_22185) 4634614..4635495 - 882 WP_022649840.1 virulence factor BrkB family protein -
NDJ97_RS22195 (NDJ97_22190) 4635489..4636088 - 600 WP_022649841.1 glucose-1-phosphatase -
NDJ97_RS22200 (NDJ97_22195) 4636207..4637007 - 801 WP_022649842.1 DeoR/GlpR family DNA-binding transcription regulator -
NDJ97_RS22205 (NDJ97_22200) 4637042..4637938 - 897 WP_022649843.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12148.13 Da        Isoelectric Point: 9.4455

>T247702 WP_022649837.1 NZ_CP098486:c4633045-4632734 [Enterobacter hormaechei subsp. hormaechei]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPDYGDLIQNTGGLRKIRWLAGGKGKRSGVRVIYFHRTRECEIRLLLIY
RKGIKDDLSAGEKAILKKMIERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10699.21 Da        Isoelectric Point: 10.5888

>AT247702 WP_022649836.1 NZ_CP098486:c4632733-4632443 [Enterobacter hormaechei subsp. hormaechei]
MDKALFERLTQSIAQINEIAEGQREPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALTQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A155DUZ6

Antitoxin

Source ID Structure

References