247633

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4626727..4627329 Replicon chromosome
Accession NZ_CP098438
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATOMSal-L6

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag M9193_RS22290 Protein ID WP_001159630.1
Coordinates 4627018..4627329 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M9193_RS22285 Protein ID WP_000362050.1
Coordinates 4626727..4627017 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9193_RS22270 (4624220) 4624220..4625122 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
M9193_RS22275 (4625119) 4625119..4625754 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
M9193_RS22280 (4625751) 4625751..4626680 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
M9193_RS22285 (4626727) 4626727..4627017 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
M9193_RS22290 (4627018) 4627018..4627329 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
M9193_RS22295 (4627547) 4627547..4628476 + 930 WP_001127703.1 alpha/beta hydrolase -
M9193_RS22300 (4628562) 4628562..4628873 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
M9193_RS22305 (4628870) 4628870..4629316 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
M9193_RS22310 (4629331) 4629331..4630272 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
M9193_RS22315 (4630317) 4630317..4630754 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
M9193_RS22320 (4630751) 4630751..4631623 - 873 WP_000921427.1 virulence factor BrkB family protein -
M9193_RS22325 (4631617) 4631617..4632216 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T247633 WP_001159630.1 NZ_CP098438:c4627329-4627018 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT247633 WP_000362050.1 NZ_CP098438:c4627017-4626727 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References