Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4304947..4305728 Replicon chromosome
Accession NZ_CP098438
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATOMSal-L6

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag M9193_RS20850 Protein ID WP_000626099.1
Coordinates 4304947..4305438 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag M9193_RS20855 Protein ID WP_001110452.1
Coordinates 4305435..4305728 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9193_RS20815 (4300943) 4300943..4301518 + 576 WP_001188509.1 transcriptional regulator -
M9193_RS20825 (4301789) 4301789..4301866 - 78 Protein_4070 helix-turn-helix domain-containing protein -
M9193_RS20830 (4301957) 4301957..4302289 - 333 WP_001165471.1 MerR family transcriptional regulator -
M9193_RS20835 (4302361) 4302361..4302738 + 378 WP_000916345.1 EthD family reductase -
M9193_RS20840 (4303770) 4303770..4303844 + 75 Protein_4073 porin family protein -
M9193_RS20845 (4303947) 4303947..4304699 + 753 WP_000842434.1 non-specific acid phosphatase -
M9193_RS20850 (4304947) 4304947..4305438 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
M9193_RS20855 (4305435) 4305435..4305728 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
M9193_RS20860 (4306045) 4306045..4306266 + 222 WP_001576552.1 hypothetical protein -
M9193_RS20865 (4306531) 4306531..4307406 + 876 WP_000921674.1 AraC family transcriptional regulator -
M9193_RS20870 (4307403) 4307403..4307690 + 288 WP_001269916.1 transcriptional regulator RtsB -
M9193_RS20875 (4307713) 4307713..4307928 + 216 WP_001595136.1 hypothetical protein -
M9193_RS20880 (4307936) 4307936..4308205 + 270 WP_010989096.1 hypothetical protein -
M9193_RS20885 (4308414) 4308414..4308872 - 459 WP_000502119.1 IS200/IS605-like element IS200F family transposase -
M9193_RS20890 (4309211) 4309211..4310116 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4308414..4308872 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T247632 WP_000626099.1 NZ_CP098438:c4305438-4304947 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT247632 WP_001110452.1 NZ_CP098438:c4305728-4305435 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References