247626

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2426626..2427148 Replicon chromosome
Accession NZ_CP098438
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATOMSal-L6

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag M9193_RS11720 Protein ID WP_000221343.1
Coordinates 2426864..2427148 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag M9193_RS11715 Protein ID WP_000885424.1
Coordinates 2426626..2426874 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9193_RS11690 (2421842) 2421842..2423308 + 1467 WP_000987828.1 hypothetical protein -
M9193_RS11695 (2424116) 2424116..2424830 + 715 Protein_2289 helix-turn-helix domain-containing protein -
M9193_RS11700 (2424886) 2424886..2425794 - 909 WP_010989018.1 hypothetical protein -
M9193_RS11705 (2425937) 2425937..2426269 - 333 WP_000253154.1 DUF1493 family protein -
M9193_RS11710 (2426259) 2426259..2426474 - 216 WP_000206207.1 hypothetical protein -
M9193_RS11715 (2426626) 2426626..2426874 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M9193_RS11720 (2426864) 2426864..2427148 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9193_RS11725 (2427319) 2427319..2427708 + 390 WP_000194089.1 RidA family protein -
M9193_RS11730 (2427760) 2427760..2428839 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
M9193_RS11735 (2429032) 2429032..2429520 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
M9193_RS11740 (2429565) 2429565..2431073 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2421845..2433930 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T247626 WP_000221343.1 NZ_CP098438:2426864-2427148 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT247626 WP_000885424.1 NZ_CP098438:2426626-2426874 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References