Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3049885..3050417 Replicon chromosome
Accession NZ_CP098437
Organism Streptomyces lydicamycinicus strain MMS22-DDSA8

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag NCG97_RS13630 Protein ID WP_251084126.1
Coordinates 3049885..3050139 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag NCG97_RS13635 Protein ID WP_251084127.1
Coordinates 3050136..3050417 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCG97_RS13620 (NCG97_13615) 3045644..3046045 + 402 WP_251084124.1 hypothetical protein -
NCG97_RS13625 (NCG97_13620) 3046325..3049840 + 3516 WP_251084125.1 ATP-binding protein -
NCG97_RS13630 (NCG97_13625) 3049885..3050139 - 255 WP_251084126.1 Txe/YoeB family addiction module toxin Toxin
NCG97_RS13635 (NCG97_13630) 3050136..3050417 - 282 WP_251084127.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
NCG97_RS13640 (NCG97_13635) 3050606..3051694 - 1089 WP_042148097.1 redox-regulated ATPase YchF -
NCG97_RS13645 (NCG97_13640) 3052380..3052532 - 153 WP_158894227.1 hypothetical protein -
NCG97_RS13650 (NCG97_13645) 3052613..3053506 - 894 WP_042148094.1 ROK family protein -
NCG97_RS13655 (NCG97_13650) 3053592..3054611 - 1020 WP_063770768.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-64)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.61 Da        Isoelectric Point: 8.4390

>T247615 WP_251084126.1 NZ_CP098437:c3050139-3049885 [Streptomyces lydicamycinicus]
VRLVFEDQGWEDYTSWLKNDRKMLTRINKLIEDVKRDPFEGIGKPEPLKYHLPGAWSRRIDDEHRLVYLVTGKEIVILAA
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 9987.28 Da        Isoelectric Point: 5.1133

>AT247615 WP_251084127.1 NZ_CP098437:c3050417-3050136 [Streptomyces lydicamycinicus]
MSITASEARKALFPLIKKVNDDHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANARRLLKAYENALGNINVSEREL
IDPDAVDPAAGAA

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References