Detailed information of TA system TA247607

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 354..690
• Replicon: plasmid pCQ025-3
• Accession: NZ_CP098421
• Organism: Enterococcus faecalis strain CQ025

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: NAG09_RS15220
• Protein ID: WP_141435800.1
• Coordinates: 354..500 (+)
• Length: 49 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	434..690 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NAG09_RS15220	354..500	+	147	WP_141435800.1	putative holin-like toxin	Toxin
-	434..690	-	257	-	-	Antitoxin
NAG09_RS14755	719..1195	-	477	WP_000615486.1	single-stranded DNA-binding protein	-
NAG09_RS14760	1335..2669	-	1335	WP_001036756.1	PcfJ domain-containing protein	-
NAG09_RS14765	2666..3442	-	777	WP_000347505.1	Cas9 inhibitor AcrIIA9 family protein	-
NAG09_RS14770	3604..3870	-	267	WP_001245899.1	hypothetical protein	-
NAG09_RS14775	3877..4059	-	183	WP_001808764.1	hypothetical protein	-
NAG09_RS14780	4477..4965	-	489	WP_086321361.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	dfrG / aph(3')-III / erm(B)	-	1..59669	59669

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-48)

Sequences

Toxin

Protein

• Length: 49 a.a.
• Molecular weight: 5382.49 Da
• Isoelectric Point: 10.6867

>T247607 WP_141435800.1 NZ_CP098421:354-500 [Enterococcus faecalis]
MNVLPKSIERRSLLSVSESLQLMLAFGGFTLTLITTIVAILNYKDKKK

Nucleotide

• Length: 147 bp

Antitoxin

Nucleotide

• Length: 257 bp

>AT247607 NZ_CP098421:c690-434 [Enterococcus faecalis]
CACCGCCACCGCCGTTTAGGCGCGCATGAAAAAAGGTAGGCATTCGCCTACCTTTTCGCACAAAATGTGGTATAATAATT
ATGTAAAGAGGACGTACTGGTAATACGCCCTCATTGATAGCACCGCTAAAGACGGTGGCAGAGTTTTTATAAGTTATTTA
GAAATAACCGGTCTCCTGCTAAAGTGACGGTTATTTCTTTTTGTCTTTATAGTTCAGAATGGCAACAATGGTTGTGATTA
GGGTCAATGTAAACCCA

Structures

Antitoxin