Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2831638..2831975 Replicon chromosome
Accession NZ_CP098418
Organism Enterococcus faecalis strain CQ025

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag NAG09_RS13680 Protein ID WP_002396786.1
Coordinates 2831638..2831781 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2831713..2831975 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG09_RS13665 (2827354) 2827354..2827986 - 633 WP_002358972.1 RloB family protein -
NAG09_RS13670 (2827995) 2827995..2829290 - 1296 WP_002410675.1 ATP-binding protein -
NAG09_RS13675 (2829752) 2829752..2831368 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -
NAG09_RS13680 (2831638) 2831638..2831781 + 144 WP_002396786.1 putative holin-like toxin Toxin
- (2831925) 2831925..2831974 + 50 NuclAT_8 - -
- (2831713) 2831713..2831975 - 263 NuclAT_7 - Antitoxin
NAG09_RS13685 (2831976) 2831976..2836667 - 4692 WP_250652880.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T247603 WP_002396786.1 NZ_CP098418:2831638-2831781 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 263 bp

>AT247603 NZ_CP098418:c2831975-2831713 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGACAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References