Detailed information of TA system TA247601

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2674988..2675213
• Replicon: chromosome
• Accession: NZ_CP098418
• Organism: Enterococcus faecalis strain CQ025

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: NAG09_RS12975
• Protein ID: WP_075551663.1
• Coordinates: 2675112..2675213 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2674988..2675167 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NAG09_RS12945 (2670206)	2670206..2671159	-	954	WP_010709946.1	siderophore ABC transporter substrate-binding protein	-
NAG09_RS12950 (2671198)	2671198..2671953	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
NAG09_RS12955 (2671950)	2671950..2672915	-	966	WP_016622541.1	iron chelate uptake ABC transporter family permease subunit	-
NAG09_RS12960 (2672912)	2672912..2673859	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
NAG09_RS12965 (2674044)	2674044..2674496	+	453	WP_002359057.1	YueI family protein	-
- (2674522)	2674522..2674729	+	208	NuclAT_3	-	-
- (2674559)	2674559..2674733	+	175	NuclAT_6	-	-
NAG09_RS12970 (2674678)	2674678..2674779	-	102	WP_021164441.1	putative holin-like toxin	-
- (2674954)	2674954..2675163	+	210	NuclAT_4	-	-
- (2674988)	2674988..2675167	+	180	NuclAT_5	-	Antitoxin
NAG09_RS12975 (2675112)	2675112..2675213	-	102	WP_075551663.1	putative holin-like toxin	Toxin
NAG09_RS12980 (2675401)	2675401..2677671	-	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
NAG09_RS12985 (2677842)	2677842..2678342	+	501	WP_010709949.1	cysteine hydrolase family protein	-
NAG09_RS12990 (2679043)	2679043..2679939	+	897	WP_002354953.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T247601 WP_075551663.1 NZ_CP098418:c2675213-2675112 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 180 bp

>AT247601 NZ_CP098418:2674988-2675167 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Structures

Antitoxin