Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 501723..501955 Replicon chromosome
Accession NZ_CP098418
Organism Enterococcus faecalis strain CQ025

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag NAG09_RS02440 Protein ID WP_002355568.1
Coordinates 501723..501839 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 501750..501955 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAG09_RS02430 (497161) 497161..499419 + 2259 WP_002363179.1 DNA helicase PcrA -
NAG09_RS02435 (499545) 499545..501575 + 2031 WP_002364804.1 NAD-dependent DNA ligase LigA -
NAG09_RS02440 (501723) 501723..501839 + 117 WP_002355568.1 putative holin-like toxin Toxin
- (501750) 501750..501955 - 206 NuclAT_2 - Antitoxin
NAG09_RS02445 (502157) 502157..502462 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
NAG09_RS02450 (502462) 502462..503940 + 1479 WP_016622625.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
NAG09_RS02455 (503930) 503930..505360 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
NAG09_RS02460 (505379) 505379..506467 + 1089 WP_002355572.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T247592 WP_002355568.1 NZ_CP098418:501723-501839 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT247592 NZ_CP098418:c501955-501750 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References