Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1389954..1390518 Replicon chromosome
Accession NZ_CP098411
Organism Lacticaseibacillus paracasei strain 401

Toxin (Protein)


Gene name yafQ Uniprot ID K6S2P8
Locus tag NCY29_RS06775 Protein ID WP_003602097.1
Coordinates 1390216..1390518 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID K6SLT0
Locus tag NCY29_RS06770 Protein ID WP_003570051.1
Coordinates 1389954..1390223 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCY29_RS06740 (NCY29_06740) 1384959..1385846 - 888 WP_063558064.1 ABC transporter ATP-binding protein -
NCY29_RS06745 (NCY29_06745) 1386043..1387269 - 1227 WP_250786116.1 hypothetical protein -
NCY29_RS06750 (NCY29_06750) 1387467..1387871 + 405 WP_063558066.1 MerR family transcriptional regulator -
NCY29_RS06755 (NCY29_06755) 1387864..1388190 + 327 WP_063558067.1 YrdB family protein -
NCY29_RS06760 (NCY29_06760) 1388253..1388882 + 630 Protein_1311 DUF2399 domain-containing protein -
NCY29_RS06765 (NCY29_06765) 1388927..1389580 + 654 WP_063558068.1 N-acetyltransferase -
NCY29_RS06770 (NCY29_06770) 1389954..1390223 + 270 WP_003570051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NCY29_RS06775 (NCY29_06775) 1390216..1390518 + 303 WP_003602097.1 type II toxin-antitoxin system YafQ family toxin Toxin
NCY29_RS06780 (NCY29_06780) 1390857..1391000 + 144 WP_162259784.1 hypothetical protein -
NCY29_RS06785 (NCY29_06785) 1391227..1391814 + 588 WP_063558069.1 hypothetical protein -
NCY29_RS06790 (NCY29_06790) 1392050..1394227 + 2178 WP_063558070.1 Tex family protein -
NCY29_RS06795 (NCY29_06795) 1394652..1395209 - 558 WP_063558071.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1372809..1409872 37063


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11442.21 Da        Isoelectric Point: 9.9697

>T247587 WP_003602097.1 NZ_CP098411:1390216-1390518 [Lacticaseibacillus paracasei]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELHVDGPRGDWLLIYKIE
QQDLILTLVRTGSHHNLLGK

Download         Length: 303 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9950.62 Da        Isoelectric Point: 7.2026

>AT247587 WP_003570051.1 NZ_CP098411:1389954-1390223 [Lacticaseibacillus paracasei]
VAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K6S2P8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2BRK6

References