Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe(toxin)
Location 737581..738113 Replicon chromosome
Accession NZ_CP098403
Organism Lactobacillus kefiranofaciens subsp. kefirgranum strain HL1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A656YA18
Locus tag MU859_RS03845 Protein ID WP_013854119.1
Coordinates 737581..737850 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A656Y9W5
Locus tag MU859_RS03850 Protein ID WP_013854120.1
Coordinates 737847..738113 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU859_RS03820 (MU859_03820) 732587..733216 - 630 WP_054640431.1 Crp/Fnr family transcriptional regulator -
MU859_RS03825 (MU859_03825) 733235..733786 - 552 WP_013854115.1 DNA-binding protein -
MU859_RS03830 (MU859_03830) 733786..734016 - 231 WP_013854116.1 cation transporter -
MU859_RS03835 (MU859_03835) 734039..735940 - 1902 WP_188891291.1 heavy metal translocating P-type ATPase -
MU859_RS03840 (MU859_03840) 736058..737395 - 1338 WP_025084196.1 MATE family efflux transporter -
MU859_RS03845 (MU859_03845) 737581..737850 - 270 WP_013854119.1 Txe/YoeB family addiction module toxin Toxin
MU859_RS03850 (MU859_03850) 737847..738113 - 267 WP_013854120.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MU859_RS03855 (MU859_03855) 738364..739227 - 864 WP_056941350.1 alpha/beta hydrolase -
MU859_RS03860 (MU859_03860) 739224..740393 - 1170 WP_013854123.1 MalY/PatB family protein -
MU859_RS03865 (MU859_03865) 740399..741292 - 894 WP_013854124.1 DUF3737 family protein -
MU859_RS03870 (MU859_03870) 741351..741668 - 318 WP_025084192.1 carboxymuconolactone decarboxylase family protein -
MU859_RS03875 (MU859_03875) 741678..742093 - 416 Protein_731 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(26-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-67)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10617.35 Da        Isoelectric Point: 10.4670

>T247582 WP_013854119.1 NZ_CP098403:c737850-737581 [Lactobacillus kefiranofaciens subsp. kefirgranum]
MILKYHGRIKNSAKPDLKKIKRSNLKDNFQDIIDQLKKDPYKKNQGFEKLEPPILGKYSRRINIKHRVVYTVDDVNKIVS
IYSAWSHYE

Download         Length: 270 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9984.05 Da        Isoelectric Point: 4.4857

>AT247582 WP_013854120.1 NZ_CP098403:c738113-737847 [Lactobacillus kefiranofaciens subsp. kefirgranum]
MDATIYTPTGARRNLFNLIKQVNKNHTPVNIESTKDKAESAVLISKSDWDAIQETLYLESNGVGEVVRKREKDNSGFTDI
DDINWDEL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656YA18

Antitoxin

Source ID Structure
AlphaFold DB A0A656Y9W5

References