Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 736489..737264 Replicon chromosome
Accession NZ_CP098355
Organism Klebsiella pneumoniae strain 13001

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag NB672_RS03680 Protein ID WP_004150910.1
Coordinates 736779..737264 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag NB672_RS03675 Protein ID WP_004150912.1
Coordinates 736489..736782 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB672_RS03655 (NB672_03655) 731697..732299 - 603 WP_002916735.1 short chain dehydrogenase -
NB672_RS03660 (NB672_03660) 732397..733308 + 912 WP_004188550.1 LysR family transcriptional regulator -
NB672_RS03665 (NB672_03665) 733309..734457 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
NB672_RS03670 (NB672_03670) 734468..735844 - 1377 WP_004217775.1 cystathionine beta-synthase -
NB672_RS03675 (NB672_03675) 736489..736782 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
NB672_RS03680 (NB672_03680) 736779..737264 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
NB672_RS03685 (NB672_03685) 737968..738561 + 594 WP_004188553.1 hypothetical protein -
NB672_RS03690 (NB672_03690) 738658..738874 + 217 Protein_725 transposase -
NB672_RS03695 (NB672_03695) 739480..740352 + 873 WP_004188557.1 ParA family protein -
NB672_RS03700 (NB672_03700) 740352..740735 + 384 WP_004150906.1 hypothetical protein -
NB672_RS03705 (NB672_03705) 740728..742095 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 738658..738810 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T247567 WP_004150910.1 NZ_CP098355:736779-737264 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT247567 WP_004150912.1 NZ_CP098355:736489-736782 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References