24756

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2789693..2790936 Replicon chromosome
Accession NC_014125
Organism Legionella pneumophila 2300/99 Alcoy

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag LPA_RS12335 Protein ID WP_011947284.1
Coordinates 2789998..2790936 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A378KAQ5
Locus tag LPA_RS12330 Protein ID WP_013101793.1
Coordinates 2789693..2790001 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPA_RS12295 2785165..2786025 + 861 WP_011947276.1 DUF2608 domain-containing protein -
LPA_RS12300 2786375..2786674 - 300 WP_013101791.1 hypothetical protein -
LPA_RS12305 2786685..2786996 - 312 WP_011947278.1 cupin -
LPA_RS12310 2787012..2787269 - 258 WP_011947279.1 hypothetical protein -
LPA_RS12315 2787445..2787918 + 474 WP_011947280.1 hypothetical protein -
LPA_RS12320 2788108..2789025 + 918 WP_011947281.1 LysR family transcriptional regulator -
LPA_RS12325 2789469..2789696 + 228 WP_013101792.1 helix-turn-helix transcriptional regulator -
LPA_RS12330 2789693..2790001 + 309 WP_013101793.1 HipA N-terminal domain-containing protein Antitoxin
LPA_RS12335 2789998..2790936 + 939 WP_011947284.1 HipA domain-containing protein Toxin
LPA_RS12340 2791099..2791809 - 711 WP_013101794.1 outer membrane beta-barrel protein -
LPA_RS12345 2792292..2792585 - 294 WP_011947286.1 SNARE domain-containing protein -
LPA_RS12350 2792613..2793512 - 900 WP_013101795.1 hypothetical protein -
LPA_RS12355 2793676..2795130 + 1455 WP_013101796.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-279)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36078.70 Da        Isoelectric Point: 9.3347

>T24756 WP_011947284.1 NC_014125:2789998-2790936 [Legionella pneumophila 2300/99 Alcoy]
MKRCPITYEKISDQENYSQRGLRLLSPQLKNLSPLDLSADEQRQEAIARVGKTSIQGVQKKLSAKLKIKEGCFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAIIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITRDRKISISPAYDLLNSTIAQKNTKEEIALLLKG
KKNNLTKSDFFNYFAVEKLGLNQNVINGIAQEFHQAIPEWRELISFSFLSQPMQEKYLQLLDQRCKRLNFFD

Download         Length: 939 bp

>T24756 NC_014125:2789998-2790936 [Legionella pneumophila 2300/99 Alcoy]
ATGAAACGCTGCCCCATTACTTATGAAAAAATCAGTGACCAAGAAAACTATTCACAACGTGGATTGCGCTTGCTTTCTCC
TCAATTAAAAAACCTGAGCCCATTAGATTTAAGTGCTGATGAGCAGCGTCAGGAAGCAATTGCTCGAGTAGGAAAGACGT
CAATTCAAGGTGTCCAAAAGAAACTAAGCGCAAAACTAAAGATTAAAGAGGGATGTTTTGAAATCGTGGATCAAAATGGT
CACTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCGGAAAACGAAGCCATTACCATGACCCTTGCAAAGAC
CATTGGACTTGAAGTGCCTGTTCATGGTTTAGTGTACTCTAAAGATAACAGTTTGACTTACTTCATTAAACGGTTTGATA
GAATAGGCCATAATAAAAAATTAGCTTTAGAAGATTTTGCACAGCTATCGGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTGATTGCAATCATAGAGCAGTTTTGCACGTTCCCCAAAATTGAATTCGTGAAATTATTTAAGTTGAC
ATTGTTTAACTTCCTGGTCGGCAATGAAGACATGCACCTAAAAAATTTTTCTCTAATTACCAGGGATAGAAAAATTTCCA
TATCACCAGCATACGATTTACTTAACTCAACTATCGCTCAAAAAAACACAAAAGAAGAAATCGCATTGCTCCTCAAAGGG
AAAAAAAATAATTTAACAAAGAGTGATTTTTTTAACTATTTTGCCGTTGAAAAATTAGGATTAAATCAGAACGTCATCAA
TGGGATCGCACAAGAGTTTCATCAGGCAATACCAGAATGGCGAGAGTTGATTAGTTTCAGTTTTTTATCTCAACCGATGC
AGGAAAAATATCTCCAATTGCTCGATCAACGATGCAAGAGATTAAATTTTTTTGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11586.38 Da        Isoelectric Point: 4.5859

>AT24756 WP_013101793.1 NC_014125:2789693-2790001 [Legionella pneumophila 2300/99 Alcoy]
MRKAYVSVNGIKAGILEELQSGKYQFSYFDDYHGAPVSLTMPLTNKVYDFDVFPPFFEGLLPEGIMIEALLRKYKIDKND
YFGQLIIVGQDVVGAVTIEEIR

Download         Length: 309 bp

>AT24756 NC_014125:2789693-2790001 [Legionella pneumophila 2300/99 Alcoy]
ATGAGAAAAGCATACGTATCAGTGAATGGCATCAAGGCTGGAATATTAGAAGAATTACAAAGCGGAAAATATCAATTCAG
TTACTTTGATGATTATCACGGGGCACCTGTTTCTCTCACAATGCCGTTAACCAATAAGGTCTATGATTTTGATGTATTTC
CCCCTTTTTTTGAAGGGTTACTCCCTGAAGGCATTATGATTGAAGCACTATTACGCAAATATAAAATCGATAAAAATGAT
TATTTTGGCCAATTGATAATAGTTGGCCAGGATGTCGTAGGCGCAGTGACTATTGAGGAAATAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A378KAQ5

References