Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1135581..1136308 Replicon chromosome
Accession NZ_CP098325
Organism Leclercia adecarboxylata strain kcgeb_e1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NB069_RS05285 Protein ID WP_250588221.1
Coordinates 1135997..1136308 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NB069_RS05280 Protein ID WP_250588219.1
Coordinates 1135581..1136000 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB069_RS05270 (NB069_05270) 1131319..1134453 + 3135 WP_250588212.1 efflux RND transporter permease subunit -
NB069_RS05275 (NB069_05275) 1134404..1135525 - 1122 WP_250588217.1 YbdK family carboxylate-amine ligase -
NB069_RS05280 (NB069_05280) 1135581..1136000 - 420 WP_250588219.1 helix-turn-helix domain-containing protein Antitoxin
NB069_RS05285 (NB069_05285) 1135997..1136308 - 312 WP_250588221.1 type II toxin-antitoxin system HigB family toxin Toxin
NB069_RS05290 (NB069_05290) 1136595..1136840 + 246 WP_250588222.1 YmjA family protein -
NB069_RS05295 (NB069_05295) 1136936..1137424 + 489 WP_250588224.1 cold shock domain-containing protein -
NB069_RS05300 (NB069_05300) 1137521..1138225 - 705 WP_250588226.1 ABC transporter ATP-binding protein -
NB069_RS05305 (NB069_05305) 1138212..1139048 - 837 WP_250588227.1 ABC transporter ATP-binding protein -
NB069_RS05310 (NB069_05310) 1139041..1139874 - 834 WP_250588229.1 ABC transporter permease -
NB069_RS05315 (NB069_05315) 1139874..1140896 - 1023 WP_250588231.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12455.50 Da        Isoelectric Point: 10.5920

>T247410 WP_250588221.1 NZ_CP098325:c1136308-1135997 [Leclercia adecarboxylata]
MHVVSRAPFDIATRRFPNQALALQDLYRVLKKEIYPSPDLMRKRFPSLDRMKYREKWWVIDVGGGHLRVIFFADFERGRI
FIKHISTHAEYDKLTDVYRRTKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15528.73 Da        Isoelectric Point: 6.0900

>AT247410 WP_250588219.1 NZ_CP098325:c1136000-1135581 [Leclercia adecarboxylata]
MNYAQAIKAANDLANVLPFLGARPSRKDYEDALALVEYLIEHQPDSPLIDMLTARIDKYEHESPEFAGFNGRIASTPSGV
ALLRTLMDQYHLTQSDLENEIGKKSLVSRILKGERTLTLDHMRALAKRFDLPVSAFVGN

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References