Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1110132..1110781 Replicon chromosome
Accession NZ_CP098325
Organism Leclercia adecarboxylata strain kcgeb_e1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NB069_RS05180 Protein ID WP_250588171.1
Coordinates 1110419..1110781 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NB069_RS05175 Protein ID WP_250588170.1
Coordinates 1110132..1110431 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB069_RS05165 (NB069_05165) 1106572..1108533 + 1962 WP_250588166.1 PhoX family phosphatase -
NB069_RS05170 (NB069_05170) 1108637..1110025 + 1389 WP_250588168.1 phenylalanine transporter -
NB069_RS05175 (NB069_05175) 1110132..1110431 - 300 WP_250588170.1 helix-turn-helix transcriptional regulator Antitoxin
NB069_RS05180 (NB069_05180) 1110419..1110781 - 363 WP_250588171.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NB069_RS05185 (NB069_05185) 1111054..1112292 + 1239 WP_250588179.1 MFS transporter -
NB069_RS05190 (NB069_05190) 1112307..1113332 + 1026 WP_250588181.1 sugar phosphate isomerase/epimerase -
NB069_RS05195 (NB069_05195) 1113325..1114467 + 1143 WP_250588183.1 Gfo/Idh/MocA family oxidoreductase -
NB069_RS05200 (NB069_05200) 1114543..1115523 + 981 WP_250588184.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-88)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13853.82 Da        Isoelectric Point: 8.0460

>T247409 WP_250588171.1 NZ_CP098325:c1110781-1110419 [Leclercia adecarboxylata]
MWEVETTDKFDEWFHNQKQALKEDILAALHILSEYGPQLGRPFVDTLKGSQFTNMKELRIQHAGDPVRAFFAFDPGRKAI
ILCAGNKTGTAEKRFYKQMIAIADAEFSKYLANQEAKWQR

Download         Length: 363 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11061.81 Da        Isoelectric Point: 5.8787

>AT247409 WP_250588170.1 NZ_CP098325:c1110431-1110132 [Leclercia adecarboxylata]
MATLKELMARQSEESQERIVAKVEELRIIVALNQLREELNISQTELAAAMGVKQPTIAKIEQTDNDPRLSTLKRYVTALG
GEVSIDVILPTGKRVAFHF

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References