Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3189085..3189705 Replicon chromosome
Accession NZ_CP098322
Organism Burkholderia gladioli strain BK04

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NAL90_RS31915 Protein ID WP_105827411.1
Coordinates 3189427..3189705 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A560VTG3
Locus tag NAL90_RS31910 Protein ID WP_029951048.1
Coordinates 3189085..3189408 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NAL90_RS31890 (NAL90_31880) 3184798..3185211 - 414 WP_013690200.1 MarR family transcriptional regulator -
NAL90_RS31895 (NAL90_31885) 3185319..3186497 - 1179 WP_250805058.1 HPP family protein -
NAL90_RS31900 (NAL90_31890) 3186892..3187848 + 957 WP_025100402.1 LysR family transcriptional regulator -
NAL90_RS31905 (NAL90_31895) 3187892..3188977 - 1086 WP_105858126.1 ionic transporter y4hA -
NAL90_RS31910 (NAL90_31900) 3189085..3189408 - 324 WP_029951048.1 HigA family addiction module antitoxin Antitoxin
NAL90_RS31915 (NAL90_31905) 3189427..3189705 - 279 WP_105827411.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NAL90_RS31920 (NAL90_31910) 3189948..3190616 + 669 WP_025100406.1 MarC family protein -
NAL90_RS31925 (NAL90_31915) 3190734..3191603 - 870 WP_105852705.1 CPBP family intramembrane metalloprotease -
NAL90_RS31930 (NAL90_31920) 3191877..3192599 - 723 WP_250805059.1 fumarylacetoacetate hydrolase family protein -
NAL90_RS31935 (NAL90_31925) 3192748..3193848 - 1101 WP_186036216.1 helix-turn-helix transcriptional regulator -
NAL90_RS31940 (NAL90_31930) 3194041..3194643 - 603 WP_013690210.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(25-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(13-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10429.06 Da        Isoelectric Point: 9.9309

>T247403 WP_105827411.1 NZ_CP098322:c3189705-3189427 [Burkholderia gladioli]
MIQSFRCKRTAALFAGESPPAWRAVVQVARRKLAMLDAAQALRDLAVPPGNQLEGLFGDRAGQYSIRINERWRLCFVWSS
RGPELVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11903.72 Da        Isoelectric Point: 7.2024

>AT247403 WP_029951048.1 NZ_CP098322:c3189408-3189085 [Burkholderia gladioli]
MNAKSVKPVNAMPAIHPGEILREEFLVPLALSVNALSLALMVPATRMHEIVNERRGITADTAYRLSRYFGTTPEFWLALQ
ADYDIKTLPNRDEIDRKVDARPNGAAA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A560VTG3

References