Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1821053..1821576 Replicon chromosome
Accession NZ_CP098257
Organism Staphylococcus aureus strain M4

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2W3LFI1
Locus tag NB631_RS08585 Protein ID WP_000074047.1
Coordinates 1821310..1821576 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag NB631_RS08580 Protein ID WP_000587617.1
Coordinates 1821053..1821310 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB631_RS08560 (NB631_08565) 1816131..1817324 + 1194 WP_000675407.1 MFS transporter -
NB631_RS08565 (NB631_08570) 1817548..1818297 - 750 WP_000072447.1 CPBP family lipoprotein N-acylation protein LnsB -
NB631_RS08570 (NB631_08575) 1818493..1820070 + 1578 WP_000143489.1 FMN-binding glutamate synthase family protein -
NB631_RS08575 (NB631_08580) 1820238..1820693 - 456 WP_000732090.1 YehR family lipoprotein -
NB631_RS08580 (NB631_08585) 1821053..1821310 + 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NB631_RS08585 (NB631_08590) 1821310..1821576 + 267 WP_000074047.1 Txe/YoeB family addiction module toxin Toxin
NB631_RS08590 (NB631_08595) 1821932..1823008 + 1077 WP_001076679.1 M42 family metallopeptidase -
NB631_RS08595 (NB631_08600) 1823354..1824016 + 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
NB631_RS08600 (NB631_08605) 1824009..1824785 + 777 WP_000072154.1 iron export ABC transporter permease subunit FetB -
NB631_RS08605 (NB631_08610) 1825179..1826366 + 1188 WP_000026190.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.1384

>T247388 WP_000074047.1 NZ_CP098257:1821310-1821576 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT247388 WP_000587617.1 NZ_CP098257:1821053-1821310 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W3LFI1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References