247377

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1877675..1878192 Replicon chromosome
Accession NZ_CP098255
Organism Staphylococcus aureus strain N4

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag NB630_RS08865 Protein ID WP_000251928.1
Coordinates 1877926..1878192 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag NB630_RS08860 Protein ID WP_000584497.1
Coordinates 1877675..1877926 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB630_RS08830 (NB630_08830) 1873375..1874094 + 720 WP_000479573.1 amino acid ABC transporter permease -
NB630_RS08835 (NB630_08835) 1874091..1874822 + 732 WP_000615465.1 amino acid ABC transporter ATP-binding protein -
NB630_RS08840 (NB630_08840) 1874919..1876169 - 1251 Protein_1741 FemA/FemB family glycyltransferase FmhA -
NB630_RS08845 (NB630_08845) 1876424..1876786 + 363 WP_000819843.1 DUF4467 domain-containing protein -
NB630_RS08850 (NB630_08850) 1876805..1877404 + 600 WP_000162804.1 DsbA family protein -
NB630_RS08855 (NB630_08855) 1877411..1877511 + 101 Protein_1744 hypothetical protein -
NB630_RS08860 (NB630_08860) 1877675..1877926 + 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NB630_RS08865 (NB630_08865) 1877926..1878192 + 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
NB630_RS08870 (NB630_08870) 1878485..1880032 + 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NB630_RS08875 (NB630_08875) 1880218..1880685 + 468 WP_000153340.1 SRPBCC domain-containing protein -
NB630_RS08880 (NB630_08880) 1880772..1880954 + 183 WP_000079140.1 hypothetical protein -
NB630_RS08885 (NB630_08885) 1881157..1881981 + 825 WP_000594640.1 formate/nitrite transporter family protein -
NB630_RS08890 (NB630_08890) 1882448..1882984 + 537 WP_000024292.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T247377 WP_000251928.1 NZ_CP098255:1877926-1878192 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT247377 WP_000584497.1 NZ_CP098255:1877675-1877926 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References