247364

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1877684..1878201 Replicon chromosome
Accession NZ_CP098253
Organism Staphylococcus aureus strain M0

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag NB629_RS08860 Protein ID WP_000251928.1
Coordinates 1877935..1878201 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag NB629_RS08855 Protein ID WP_000584497.1
Coordinates 1877684..1877935 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB629_RS08825 (NB629_08825) 1873384..1874103 + 720 WP_000479573.1 amino acid ABC transporter permease -
NB629_RS08830 (NB629_08830) 1874100..1874831 + 732 WP_000615465.1 amino acid ABC transporter ATP-binding protein -
NB629_RS08835 (NB629_08835) 1874928..1876178 - 1251 Protein_1740 FemA/FemB family glycyltransferase FmhA -
NB629_RS08840 (NB629_08840) 1876433..1876795 + 363 WP_000819843.1 DUF4467 domain-containing protein -
NB629_RS08845 (NB629_08845) 1876814..1877413 + 600 WP_000162804.1 DsbA family protein -
NB629_RS08850 (NB629_08850) 1877420..1877520 + 101 Protein_1743 hypothetical protein -
NB629_RS08855 (NB629_08855) 1877684..1877935 + 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NB629_RS08860 (NB629_08860) 1877935..1878201 + 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
NB629_RS08865 (NB629_08865) 1878494..1880041 + 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
NB629_RS08870 (NB629_08870) 1880227..1880694 + 468 WP_000153340.1 SRPBCC domain-containing protein -
NB629_RS08875 (NB629_08875) 1880781..1880963 + 183 WP_000079140.1 hypothetical protein -
NB629_RS08880 (NB629_08880) 1881166..1881990 + 825 WP_000594640.1 formate/nitrite transporter family protein -
NB629_RS08885 (NB629_08885) 1882457..1882993 + 537 WP_000024292.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T247364 WP_000251928.1 NZ_CP098253:1877935-1878201 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT247364 WP_000584497.1 NZ_CP098253:1877684-1877935 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References