Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 161124..161721 Replicon chromosome
Accession NZ_CP098251
Organism Oxalobacter aliiformigenes strain OxK

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag NB646_RS00870 Protein ID WP_269316016.1
Coordinates 161443..161721 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NB646_RS00865 Protein ID WP_269316015.1
Coordinates 161124..161429 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB646_RS00835 (NB646_00835) 156528..156737 + 210 WP_269277221.1 AlpA family transcriptional regulator -
NB646_RS00840 (NB646_00840) 156749..157675 + 927 WP_269316010.1 toprim domain-containing protein -
NB646_RS00845 (NB646_00845) 157672..159483 + 1812 WP_269316011.1 DUF927 domain-containing protein -
NB646_RS00850 (NB646_00850) 159963..160235 + 273 WP_269316012.1 hypothetical protein -
NB646_RS00855 (NB646_00855) 160248..160853 + 606 WP_269316013.1 hypothetical protein -
NB646_RS00860 160873..160998 + 126 WP_269316014.1 hypothetical protein -
NB646_RS00865 (NB646_00860) 161124..161429 - 306 WP_269316015.1 HigA family addiction module antitoxin Antitoxin
NB646_RS00870 (NB646_00865) 161443..161721 - 279 WP_269316016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NB646_RS00875 (NB646_00870) 162114..162350 + 237 WP_269316017.1 hypothetical protein -
NB646_RS00880 (NB646_00875) 162343..162612 + 270 WP_269316018.1 DUF3077 domain-containing protein -
NB646_RS00885 (NB646_00880) 162722..162982 - 261 WP_269316019.1 hypothetical protein -
NB646_RS00890 (NB646_00885) 164824..165078 + 255 WP_269316020.1 hypothetical protein -
NB646_RS00895 (NB646_00890) 165125..166084 + 960 WP_269316021.1 tetratricopeptide repeat protein -
NB646_RS00900 (NB646_00895) 166202..166540 + 339 WP_269264601.1 CidA/LrgA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(25-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-95)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10606.24 Da        Isoelectric Point: 9.8920

>T247359 WP_269316016.1 NZ_CP098251:c161721-161443 [Oxalobacter aliiformigenes]
MIQSFSCADTQALFAGRSVPRFVNIRTVAERKLQMLHRAVCLDDLRIPPNNRLEALKGDRKGQYSIRINGQWRLCFRFEG
GHAFDVAIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11480.15 Da        Isoelectric Point: 5.6319

>AT247359 WP_269316015.1 NZ_CP098251:c161429-161124 [Oxalobacter aliiformigenes]
MDEVINGMRPVHPGEILREEFLKPLNLSANGLAIDLHVPAPRINDIVREKRGITADTALRLARYFGTSAEFWLGLQDDYD
LKTCREQLHDTLDRIVPRATV

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References