Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2149354..2149949 Replicon chromosome
Accession NZ_CP098247
Organism Oxalobacter aliiformigenes strain BA2

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag NB636_RS10415 Protein ID WP_269280773.1
Coordinates 2149671..2149949 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NB636_RS10410 Protein ID WP_269280775.1
Coordinates 2149354..2149659 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB636_RS10390 (NB636_10355) 2144797..2145135 - 339 WP_269264601.1 CidA/LrgA family protein -
NB636_RS10395 (NB636_10360) 2145254..2146213 - 960 WP_269280779.1 tetratricopeptide repeat protein -
NB636_RS10400 (NB636_10365) 2146261..2146515 - 255 WP_269264599.1 hypothetical protein -
NB636_RS10405 (NB636_10370) 2148590..2149219 + 630 WP_269280777.1 hypothetical protein -
NB636_RS10410 (NB636_10375) 2149354..2149659 - 306 WP_269280775.1 HigA family addiction module antitoxin Antitoxin
NB636_RS10415 (NB636_10380) 2149671..2149949 - 279 WP_269280773.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NB636_RS10420 (NB636_10385) 2150764..2151054 + 291 WP_269280770.1 BRO family protein -
NB636_RS10425 (NB636_10390) 2151051..2151347 + 297 WP_269280767.1 hypothetical protein -
NB636_RS10430 (NB636_10395) 2151611..2151895 - 285 WP_269280764.1 hypothetical protein -
NB636_RS10435 (NB636_10400) 2151892..2153073 - 1182 WP_269295611.1 DUF927 domain-containing protein -
NB636_RS10440 (NB636_10405) 2153022..2154461 - 1440 Protein_2037 DUF927 domain-containing protein -
NB636_RS10445 (NB636_10410) 2154584..2154829 - 246 WP_269280759.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-86)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10707.39 Da        Isoelectric Point: 10.2305

>T247358 WP_269280773.1 NZ_CP098247:c2149949-2149671 [Oxalobacter aliiformigenes]
MIQSFSCTDTQALFAGRSVPRFVNIRTVAERKLQMLHRAVCLDDLRIPPNNRLEALKGDRKKQYSIRINGQWRLCFRFEG
GHAFDVAIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11408.04 Da        Isoelectric Point: 5.6254

>AT247358 WP_269280775.1 NZ_CP098247:c2149659-2149354 [Oxalobacter aliiformigenes]
MDDVVNGMRPVHPGEVLREEFLKPLNLSANALAIDLHVPAPRINDIVREKRGITADTALRLARYFGTSAEFWLGLQDDYD
LKTCREQLHDTLDRIVPRVAG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References