Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1725306..1725895 Replicon chromosome
Accession NZ_CP098246
Organism Oxalobacter formigenes strain HOxSLD-2

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag NB644_RS08120 Protein ID WP_005880108.1
Coordinates 1725306..1725584 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NB644_RS08125 Protein ID WP_005880107.1
Coordinates 1725596..1725895 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB644_RS08100 (NB644_08060) 1720434..1720649 - 216 WP_005880112.1 hypothetical protein -
NB644_RS08105 (NB644_08065) 1720808..1721749 - 942 WP_005880111.1 tetratricopeptide repeat protein -
NB644_RS08110 (NB644_08070) 1721691..1723400 - 1710 WP_086131830.1 hypothetical protein -
NB644_RS08115 (NB644_08075) 1723640..1724833 - 1194 WP_005880109.1 MFS transporter -
NB644_RS08120 (NB644_08080) 1725306..1725584 + 279 WP_005880108.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NB644_RS08125 (NB644_08085) 1725596..1725895 + 300 WP_005880107.1 HigA family addiction module antitoxin Antitoxin
NB644_RS08130 (NB644_08090) 1726041..1727108 - 1068 WP_005880106.1 porin -
NB644_RS08135 (NB644_08095) 1727432..1728511 - 1080 WP_036602709.1 porin -
NB644_RS08140 (NB644_08100) 1728771..1729781 - 1011 WP_269310490.1 ADP-glyceromanno-heptose 6-epimerase -
NB644_RS08145 (NB644_08105) 1730177..1730566 + 390 WP_005880102.1 NirD/YgiW/YdeI family stress tolerance protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-86)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10670.21 Da        Isoelectric Point: 9.7825

>T247349 WP_005880108.1 NZ_CP098246:1725306-1725584 [Oxalobacter formigenes]
MIKSFTCPDTQDLFAGKTVPRFVNIRSVAERKLQMIHRATGINDLRIPPNNRLEALKGDRKGQYSIRINDQWRICFTFDN
GQAFDVSIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11408.12 Da        Isoelectric Point: 6.4636

>AT247349 WP_005880107.1 NZ_CP098246:1725596-1725895 [Oxalobacter formigenes]
MDNIINGMRPIHPGEILREEFLSPMNLSSNALAIELHVPAPRINEIVRERRSITADTALRLARYFGTSAEFWMGLQDDYD
LKTCQRKLDETLGRIIPRQ

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References