Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 638083..638672 Replicon chromosome
Accession NZ_CP098244
Organism Oxalobacter formigenes strain OxWR1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag NB639_RS02690 Protein ID WP_269307659.1
Coordinates 638394..638672 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NB639_RS02685 Protein ID WP_005880107.1
Coordinates 638083..638382 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NB639_RS02665 (NB639_02655) 633412..633801 - 390 WP_005880102.1 NirD/YgiW/YdeI family stress tolerance protein -
NB639_RS02670 (NB639_02660) 634197..635207 + 1011 WP_005880103.1 ADP-glyceromanno-heptose 6-epimerase -
NB639_RS02675 (NB639_02665) 635467..636546 + 1080 WP_036602709.1 porin -
NB639_RS02680 (NB639_02670) 636870..637937 + 1068 WP_005880106.1 porin -
NB639_RS02685 (NB639_02675) 638083..638382 - 300 WP_005880107.1 HigA family addiction module antitoxin Antitoxin
NB639_RS02690 (NB639_02680) 638394..638672 - 279 WP_269307659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NB639_RS02695 (NB639_02685) 639145..640338 + 1194 WP_269307660.1 MFS transporter -
NB639_RS02700 (NB639_02690) 640579..642288 + 1710 WP_086131830.1 hypothetical protein -
NB639_RS02705 (NB639_02695) 642230..643171 + 942 WP_005880111.1 tetratricopeptide repeat protein -
NB639_RS02710 (NB639_02700) 643330..643545 + 216 WP_005880112.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(24-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-86)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10716.30 Da        Isoelectric Point: 9.2981

>T247346 WP_269307659.1 NZ_CP098244:c638672-638394 [Oxalobacter formigenes]
MIKSFTCPDTQDLFAGKTVPRFVNIRSVAERKLQMIHRATCINDLRIPPNNRLEALKGDRKGQYSIRINDQWRICFTFDN
GQAFDVSIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11408.12 Da        Isoelectric Point: 6.4636

>AT247346 WP_005880107.1 NZ_CP098244:c638382-638083 [Oxalobacter formigenes]
MDNIINGMRPIHPGEILREEFLSPMNLSSNALAIELHVPAPRINEIVRERRSITADTALRLARYFGTSAEFWMGLQDDYD
LKTCQRKLDETLGRIIPRQ

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References